Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles
Language English Country Germany Media print-electronic
Document type Journal Article
- Keywords
- cytotoxicity, drug delivery, magnetic properties, nanoparticles, platinum,
- MeSH
- Cisplatin administration & dosage chemistry pharmacokinetics pharmacology MeSH
- Folic Acid chemistry MeSH
- Drug Delivery Systems MeSH
- Humans MeSH
- Magnetite Nanoparticles chemistry MeSH
- Cell Line, Tumor MeSH
- Platinum chemistry MeSH
- Antineoplastic Agents administration & dosage chemistry pharmacokinetics pharmacology MeSH
- Carboxymethylcellulose Sodium chemistry pharmacokinetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cisplatin MeSH
- Folic Acid MeSH
- Magnetite Nanoparticles MeSH
- Platinum MeSH
- Antineoplastic Agents MeSH
- Carboxymethylcellulose Sodium MeSH
The fabrication of nanoparticles using different formulations, and which can be used for the delivery of chemotherapeutics, has recently attracted considerable attention. We describe herein an innovative approach that may ultimately allow for the selective delivery of anticancer drugs to tumor cells by using an external magnet. A conventional antitumor drug, cisplatin, has been incorporated into new carboxymethylcellulose-stabilized magnetite nanoparticles conjugated with the fluorescent marker Alexa Fluor 488 or folic acid as targeting agent. The magnetic nanocarriers possess exceptionally high biocompatibility and colloidal stability. These cisplatin-loaded nanoparticles overcome the resistance mechanisms typical of free cisplatin. Moreover, experiments aimed at the localization of the nanoparticles driven by an external magnet in a medium that mimics physiological conditions confirmed that this localization can inhibit tumor cell growth site-specifically.
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