Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu hodnotící studie, časopisecké články
PubMed
27379992
DOI
10.1007/s00330-016-4485-1
PII: 10.1007/s00330-016-4485-1
Knihovny.cz E-zdroje
- Klíčová slova
- Ageing, Cerebral cortex, Quantitative magnetic resonance imaging, T1 relaxation, White matter,
- MeSH
- bílá hmota diagnostické zobrazování patologie MeSH
- hodnotící studie jako téma MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- magnetická rezonanční tomografie metody MeSH
- mapování mozku metody MeSH
- mozek diagnostické zobrazování patologie MeSH
- následné studie MeSH
- počítačové zpracování obrazu metody MeSH
- průřezové studie MeSH
- šedá hmota diagnostické zobrazování patologie MeSH
- senioři MeSH
- spánkový lalok diagnostické zobrazování patologie MeSH
- stárnutí patologie fyziologie MeSH
- železo analýza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- Názvy látek
- železo MeSH
OBJECTIVES: T1 relaxometry is a promising tool for the assessment of microstructural changes during brain ageing. Previous cross-sectional studies demonstrated increasing T1 values in white and decreasing T1 values in grey matter over the lifetime. However, these findings have not yet been confirmed on the basis of a longitudinal study. In this longitudinal study over 7 years, T1 relaxometry was used to investigate the dynamics of age-related microstructural changes in older healthy subjects. METHODS: T1 mapping was performed in 17 healthy subjects (range 51-77 years) at baseline and after 7 years. Advanced cortical and white matter segmentation was used to determine mean T1 values in the cortex and white matter. RESULTS: The analysis revealed a decrease of mean cortical T1 values over 7 years, the rate of T1 reduction being more prominent in subjects with higher age. T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. In contrast, mean white matter T1 values remained stable. CONCLUSIONS: T1 mapping is shown to be sensitive to age-related microstructural changes in healthy ageing subjects in a longitudinal setting. Data of a cohort in late adulthood and the senescence period demonstrate a decrease of cortical T1 values over 7 years, most likely reflecting decreasing water content and increased iron concentrations. KEY POINTS: • T1 mapping is sensitive to age-related microstructural changes in a longitudinal setting. • T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. • The rate of T1 reduction was more prominent in subjects with higher age. • These changes most likely reflect decreasing cortical water and increasing iron concentrations.
Brain Imaging Center Goethe University Frankfurt Main Germany
Department of Neurology Goethe University Frankfurt Main Germany
Department of Neurology Palacky University Olomouc Czech Republic
Dr Senckenberg Chronomedical Institute Goethe University Frankfurt Main Germany
Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK
Zobrazit více v PubMed
Radiology. 1991 Nov;181(2):545-7 PubMed
Eur Radiol. 2016 Aug;26(8):2578-86 PubMed
Magn Reson Med. 1991 Feb;17(2):402-13 PubMed
Magn Reson Imaging. 2006 Sep;24(7):877-87 PubMed
Prog Neurobiol. 2014 Jun;117:20-40 PubMed
Neuroimage. 2015 Jul 1;114:71-87 PubMed
MAGMA. 2008 Mar;21(1-2):131-47 PubMed
Magn Reson Med. 2001 Jan;45(1):71-9 PubMed
Acta Neuropathol. 1983;61(3-4):178-82 PubMed
Neurobiol Aging. 2014 Aug;35(8):1862-72 PubMed
J Neurosci Res. 1990 Dec;27(4):595-611 PubMed
Magn Reson Med. 1990 Jun;14(3):482-95 PubMed
Behav Neurol. 2000;12(4):191-200 PubMed
Acta Neurochir (Wien). 1997;139(3):249-55; discussion 255-6 PubMed
Neuroimage. 1999 Feb;9(2):195-207 PubMed
Acad Radiol. 2012 Jul;19(7):785-93 PubMed
Top Magn Reson Imaging. 2010 Apr;21(2):101-13 PubMed
J Neurosci Methods. 2009 Dec 15;185(1):15-22 PubMed
Radiology. 1990 Mar;174(3 Pt 1):675-9 PubMed
Magn Reson Med. 2009 Jan;61(1):125-35 PubMed
Exp Gerontol. 2003 Jan-Feb;38(1-2):95-9 PubMed
Magn Reson Med. 2007 Feb;57(2):308-18 PubMed
Neuroimage. 2014 May 15;92:381-97 PubMed
Neuroimage. 2014 Jun;93 Pt 2:176-88 PubMed
NMR Biomed. 2015 Jul;28(7):818-30 PubMed
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57 PubMed
Neuroimage. 2012 Jul 16;61(4):1402-18 PubMed
Magn Reson Imaging. 2009 Sep;27(7):895-906 PubMed
Magn Reson Med. 1998 Nov;40(5):749-53 PubMed
Neurobiol Aging. 2012 Mar;33(3):617.e1-9 PubMed
Magn Reson Med. 2007 Jan;57(1):192-200 PubMed
Neuroimage. 2010 Oct 1;52(4):1215-23 PubMed
Neuroimage. 1999 Feb;9(2):179-94 PubMed
Rev Neurosci. 2010;21(3):187-221 PubMed
Neuroimage. 2010 Jun;51(2):512-20 PubMed
Magn Reson Med. 2005 Jan;53(1):237-41 PubMed
J Magn Reson Imaging. 1995 Jan-Feb;5(1):43-8 PubMed
Neuroimage. 2006 Feb 1;29(3):910-22 PubMed
Mult Scler. 2010 Apr;16(4):427-33 PubMed
Neuroimage. 2004;23 Suppl 1:S208-19 PubMed
Magn Reson Med. 1994 Sep;32(3):335-41 PubMed
Health Qual Life Outcomes. 2012 Nov 22;10:138 PubMed
Neuroimage. 2014 Jan 1;84:1032-41 PubMed
J Neuropathol Exp Neurol. 2008 Dec;67(12):1205-12 PubMed
Magn Reson Imaging. 1997;15(10):1133-43 PubMed
J Neurochem. 1958 Oct;3(1):41-51 PubMed
J Magn Reson Imaging. 2016 Dec;44(6):1600-1607 PubMed
Magn Reson Med. 1991 Aug;20(2):285-91 PubMed
J Neurosci. 2013 May 8;33(19):8237-42 PubMed
