Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years
Language English Country Germany Media print-electronic
Document type Evaluation Study, Journal Article
PubMed
27379992
DOI
10.1007/s00330-016-4485-1
PII: 10.1007/s00330-016-4485-1
Knihovny.cz E-resources
- Keywords
- Ageing, Cerebral cortex, Quantitative magnetic resonance imaging, T1 relaxation, White matter,
- MeSH
- White Matter diagnostic imaging pathology MeSH
- Evaluation Studies as Topic MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Magnetic Resonance Imaging methods MeSH
- Brain Mapping methods MeSH
- Brain diagnostic imaging pathology MeSH
- Follow-Up Studies MeSH
- Image Processing, Computer-Assisted methods MeSH
- Cross-Sectional Studies MeSH
- Gray Matter diagnostic imaging pathology MeSH
- Aged MeSH
- Temporal Lobe diagnostic imaging pathology MeSH
- Aging pathology physiology MeSH
- Iron analysis MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Names of Substances
- Iron MeSH
OBJECTIVES: T1 relaxometry is a promising tool for the assessment of microstructural changes during brain ageing. Previous cross-sectional studies demonstrated increasing T1 values in white and decreasing T1 values in grey matter over the lifetime. However, these findings have not yet been confirmed on the basis of a longitudinal study. In this longitudinal study over 7 years, T1 relaxometry was used to investigate the dynamics of age-related microstructural changes in older healthy subjects. METHODS: T1 mapping was performed in 17 healthy subjects (range 51-77 years) at baseline and after 7 years. Advanced cortical and white matter segmentation was used to determine mean T1 values in the cortex and white matter. RESULTS: The analysis revealed a decrease of mean cortical T1 values over 7 years, the rate of T1 reduction being more prominent in subjects with higher age. T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. In contrast, mean white matter T1 values remained stable. CONCLUSIONS: T1 mapping is shown to be sensitive to age-related microstructural changes in healthy ageing subjects in a longitudinal setting. Data of a cohort in late adulthood and the senescence period demonstrate a decrease of cortical T1 values over 7 years, most likely reflecting decreasing water content and increased iron concentrations. KEY POINTS: • T1 mapping is sensitive to age-related microstructural changes in a longitudinal setting. • T1 decreases were predominantly localized in the lateral frontal, parietal and temporal cortex. • The rate of T1 reduction was more prominent in subjects with higher age. • These changes most likely reflect decreasing cortical water and increasing iron concentrations.
Brain Imaging Center Goethe University Frankfurt Main Germany
Department of Neurology Goethe University Frankfurt Main Germany
Department of Neurology Palacky University Olomouc Czech Republic
Dr Senckenberg Chronomedical Institute Goethe University Frankfurt Main Germany
Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK
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