A Novel Perspective on the Biology of Bilirubin in Health and Disease
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
27515064
DOI
10.1016/j.molmed.2016.07.004
PII: S1471-4914(16)30079-X
Knihovny.cz E-resources
- Keywords
- bilirubin, bilirubinomics, human health, intracellular events, redox state,
- MeSH
- Antioxidants metabolism MeSH
- Bilirubin metabolism MeSH
- Diabetes Mellitus metabolism MeSH
- Hyperbilirubinemia metabolism MeSH
- Cardiovascular Diseases metabolism MeSH
- Humans MeSH
- Neoplasms metabolism MeSH
- Nervous System Diseases metabolism MeSH
- Oxidation-Reduction MeSH
- Oxidative Stress MeSH
- Signal Transduction * MeSH
- Inflammation metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antioxidants MeSH
- Bilirubin MeSH
Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver dysfunction, recent data strongly indicate that mildly elevated bilirubin (BLB) levels can be protective against an array of diseases associated with increased oxidative stress. These clinical observations are supported by new discoveries relating to the role of BLB in immunosuppression and inhibition of protein phosphorylation, resulting in the modulation of intracellular signaling pathways in vascular biology and cancer, among others. Collectively, the evidence suggests that targeting BLB metabolism could be considered a potential therapeutic approach to ameliorate a variety of conditions.
1st Faculty of Medicine Charles University Prague Prague Czech Republic
Liver Research Center Italian Liver Foundation SS14 Km 163 5 Trieste Italy
References provided by Crossref.org
A Platform for the Synthesis of Oxidation Products of Bilirubin
The Role of Bilirubin and the Other "Yellow Players" in Neurodegenerative Diseases
