A Novel Perspective on the Biology of Bilirubin in Health and Disease
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
27515064
DOI
10.1016/j.molmed.2016.07.004
PII: S1471-4914(16)30079-X
Knihovny.cz E-zdroje
- Klíčová slova
- bilirubin, bilirubinomics, human health, intracellular events, redox state,
- MeSH
- antioxidancia metabolismus MeSH
- bilirubin metabolismus MeSH
- diabetes mellitus metabolismus MeSH
- hyperbilirubinemie metabolismus MeSH
- kardiovaskulární nemoci metabolismus MeSH
- lidé MeSH
- nádory metabolismus MeSH
- nemoci nervového systému metabolismus MeSH
- oxidace-redukce MeSH
- oxidační stres MeSH
- signální transdukce * MeSH
- zánět metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antioxidancia MeSH
- bilirubin MeSH
Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver dysfunction, recent data strongly indicate that mildly elevated bilirubin (BLB) levels can be protective against an array of diseases associated with increased oxidative stress. These clinical observations are supported by new discoveries relating to the role of BLB in immunosuppression and inhibition of protein phosphorylation, resulting in the modulation of intracellular signaling pathways in vascular biology and cancer, among others. Collectively, the evidence suggests that targeting BLB metabolism could be considered a potential therapeutic approach to ameliorate a variety of conditions.
1st Faculty of Medicine Charles University Prague Prague Czech Republic
Liver Research Center Italian Liver Foundation SS14 Km 163 5 Trieste Italy
Citace poskytuje Crossref.org
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