New evolutionary insights into the non-enzymatic origin of RNA oligomers
Language English Country United States Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
27785893
DOI
10.1002/wrna.1400
Knihovny.cz E-resources
- MeSH
- Humans MeSH
- Evolution, Molecular * MeSH
- Oligonucleotides metabolism MeSH
- Origin of Life * MeSH
- RNA metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Oligonucleotides MeSH
- RNA MeSH
We outline novel findings on the non-enzymatic polymerization of nucleotides under plausible prebiotic conditions and on the spontaneous onset of informational complexity in the founding molecule, RNA. We argue that the unique ability of 3', 5' cyclic guanosine monophosphate to form stacked architectures and polymerize in a self-sustained manner suggests that this molecule may serve as the 'seed of life' from which all self-replicating oligonucleotides can be derived via a logically complete sequence of simple events. WIREs RNA 2017, 8:e1400. doi: 10.1002/wrna.1400 For further resources related to this article, please visit the WIREs website.
Dipartimento di Scienze Ecologiche e Biologiche Università della Tuscia Viterbo Italy
Institute of Biophysics Academy of Sciences of the Czech Republic Brno Czech Republic
References provided by Crossref.org
Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context
RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview
