Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, multicentrická studie
PubMed
28059470
DOI
10.1002/jbt.21891
Knihovny.cz E-zdroje
- Klíčová slova
- diabetes, diabetic kidney disease, heavy metals, metallothionein, oxidative stress,
- MeSH
- biologické markery krev MeSH
- chronická renální insuficience krev genetika patofyziologie MeSH
- diabetes mellitus 2. typu komplikace MeSH
- diabetické nefropatie krev genetika patofyziologie MeSH
- genetické asociační studie MeSH
- jednonukleotidový polymorfismus MeSH
- ledviny patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- měď krev MeSH
- metalothionein krev genetika MeSH
- oxidační stres * MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- stupeň závažnosti nemoci MeSH
- zinek krev MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- biologické markery MeSH
- měď MeSH
- metalothionein MeSH
- MT2A protein, human MeSH Prohlížeč
- zinek MeSH
Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.
Central European Institute of Technology Brno University of Technology Brno Czech Republic
Department of Pathophysiology Faculty of Medicine Masaryk University Brno Czech Republic
Department of Physiology Faculty of Medicine Masaryk University Brno Czech Republic
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