Francisella tularensis type VI secretion system comes of age
Language English Country United States Media print-electronic
Document type Editorial, Research Support, Non-U.S. Gov't, Comment
PubMed
28060573
PubMed Central
PMC5626347
DOI
10.1080/21505594.2016.1278336
Knihovny.cz E-resources
- Keywords
- FPI, Francisella, IglE, T6SS,
- MeSH
- Bacterial Proteins MeSH
- Virulence Factors MeSH
- Francisella tularensis * MeSH
- Francisella MeSH
- Humans MeSH
- Macrophages MeSH
- Type VI Secretion Systems * MeSH
- Tularemia MeSH
- Check Tag
- Humans MeSH
- Publication type
- Comment MeSH
- Research Support, Non-U.S. Gov't MeSH
- Editorial MeSH
- Names of Substances
- Bacterial Proteins MeSH
- Virulence Factors MeSH
- Type VI Secretion Systems * MeSH
See more in PubMed
Oyston PCF, Sjöstedt A, Titball RW. Tularaemia: bioterrorism defence renews interest in Francisella tularensis. Nat Rev Microbiol 2004; :967-78; PMID:15550942; http://dx.doi.org/10.1038/nrmicro1045 PubMed DOI
Rowe HM, Huntley JF. From the outside-in: The Francisella tularensis envelope and virulence. Front Cell Infect Microbiol 2015; 5:94; PMID:26779445; http://dx.doi.org/10.3389/fcimb.2015.00094 PubMed DOI PMC
Tärnvik A. Nature of protective immunity to Francisella tularensis. Rev Infect Dis 1989; 11 440-51; PMID:2665002 PubMed
Checroun C, Wehrly TD, Fisher ER, Hayes SF, Celli J. Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication. Proc Natl Acad Sci USA 2006; 103(39):14578-83; PMID:16983090; http://dx.doi.org/10.1073/pnas.0601838103 PubMed DOI PMC
Nano FE, Zhang N, Cowley SC, Klose KE, Cheung KKM, Roberts MJ, Ludu JS, Letendre GW, Meierovics AI, Stephens GJ, et al.. A Francisella tularensis pathogenicity island required for intramacrophage growth. J Bacteriol 2004; 186:6430-6436; PMID:15375123; http://dx.doi.org/10.1128/JB.186.19.6430-6436.2004 PubMed DOI PMC
Santic M, Molmeret M, Klose KE, Jones S, Kwaik YA. The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm. Cell Microbiol 2005; 7:969-79; PMID:15953029; http://dx.doi.org/10.1111/j.1462-5822.2005.00526.x PubMed DOI
Barker JR, Klose KE. Molecular and genetic basis of pathogenesis in Francisella tularensis. Ann N Y Acad Sci 2007; 1105:138-59; PMID:17395737; http://dx.doi.org/10.1196/annals.1409.010 PubMed DOI
Nano FE, Schmerk C. The Francisella pathogenicity island. Ann N Y Acad Sci 2007; 1105:122-37; PMID:17395722; http://dx.doi.org/10.1196/annals.1409.000 PubMed DOI
Ludu JS, de Bruin OM, Duplantis BN, Schmerk CL, Chou AY, Elkins KL, Nano FE. The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system. J Bacteriol 2008; 190(13):4584-95; PMID:18469101; http://dx.doi.org/10.1128/JB.00198-08 PubMed DOI PMC
Buchan BW, McCaffrey RL, Lindemann SR, Allen LA, Jones BD. Identification of migR, a regulatory element of the Francisella tularensis live vaccine strain iglABCD virulence operon required for normal replication and trafficking in macrophages. Infect Immun 2009; 77(6):2517-29; PMID:19349423; http://dx.doi.org/10.1128/IAI.00229-09 PubMed DOI PMC
Gal-Mor O, Finlay BB. Pathogenicity islands: a molecular toolbox for bacterial virulence. Cell Microbiol 2006; 8:1707-19; PMID:16939533; http://dx.doi.org/10.1111/j.1462-5822.2006.00794.x PubMed DOI
Larsson P, Elfsmark D, Svensson K, Wikström P, Forsman M, Brettin T, Keim P, Johansson A. Molecular evolutionary consequences of niche restriction in Francisella tularensis, a facultative intracellular pathogen. PLoS Pathog 2009; 5(6):e1000472; PMID:19521508; http://dx.doi.org/10.1371/journal.ppat.1000472 PubMed DOI PMC
Golovliov I, Ericsson M, Sandström G, Tärnvik A, Sjöstedt A. Identification of proteins of Francisella tularensis induced during growth in macrophages and cloning of the gene encoding a prominently induced 23-kgdalton protein. Infect Immun 1997; 65:2183-9; PMID:9169749 PubMed PMC
Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ. Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A 2006; 103(5):1528-33; PMID:16432199; http://dx.doi.org/10.1073/pnas.0510322103 PubMed DOI PMC
Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, et al.. A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 2006; 312:1526-3; PMID:16763151. doi:10.1126/science.1128393 PubMed DOI PMC
Bönemann G, Pietrosiuk A, Mogk A. Tubules and donuts: a type VI secretion story. Mol Microbiol 2010; 76:815-21; PMID:20444095; http://dx.doi.org/10.1111/j.1365-2958.2010.07171 PubMed DOI
Pukatzki S, Ma AT, Revel AT, Sturtevant D, Mekalanos JJ. Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc Natl Acad Sci U S A 2007; 104:15508-13; PMID:17873062; http://dx.doi.org/10.1073/pnas.0706532104 PubMed DOI PMC
Shneider MM, Buth SA, Ho BT, Basler M, Mekalanos JJ, Leiman PG. PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature 2013; 500:350-3; PMID:23925114; http://dx.doi.org/10.1038/nature12453 PubMed DOI PMC
Barker JR, Chong A, Wehrly TD, Yu JJ, Rodriguez SA, Liu J, Celli J, Arulanandam BP, Klose KE. The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence. Mol Microbiol 2009; 74:1459-70; PMID:20054881 PubMed PMC
Bröms JE, Sjöstedt A, Lavander M. The role of the Francisella Tularensis pathogenicity island in Type VI secretion, intracellular survival, and modulation of host cell signaling. Front Microbiol 2010; 1:136; PMID:21687753; http://dx.doi.org/10.3389/fmicb.2010.00136 PubMed DOI PMC
Clemens DL, Ge P, Lee B-Y, Horwitz MA, Zhou ZH. Atomic structure of T6SS reveals interlaced array essential to function. Cell 2015; 160:940-951; PMID:25723168; http://dx.doi.org/10.1016/j.cell.2015.02.005 PubMed DOI PMC
de Bruin OM, Duplantis BN, Ludu JS, Hare RF, Nix EB, Schmerk CL, Robb CS, Boraston AB, Hueffer K, Nano FE. The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion. Microbiology 2011. December; 157(Pt 12):3483-91; PMID:21980115; http://dx.doi.org/10.1099/mic.0.052308-0 PubMed DOI PMC
Rigard M, Bröms JE, Mosnier A, Hologne M, Martin A, Lindgren L, Punginelli C, Lays C, Walker O, Charbit A, et al.. Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence. PLoS Pathog 2016; 12:e1005821; PMID:27602570; http://dx.doi.org/10.1371/journal.ppat.1005821 PubMed DOI PMC
Bröms JE, Meyer L, Sun K, Lavander M, Sjöstedt A. Unique substrates secreted by the type VI secretion system of Francisella tularensis during intramacrophage infection. PLoS One 2012; 7:e50473; PMID:23185631; http://dx.doi.org/10.1371/journal.pone.0050473 PubMed DOI PMC
Robertson GT, Child R, Ingle C, Celli J, Norgard MV. IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A Francisella tularensis. Infect Immun 2013; 81:4026-40; PMID:23959721; http://dx.doi.org/10.1128/IAI.00595-13 PubMed DOI PMC
Nguyen JQ, Gilley RP, Zogaj X, Rodriguez SA, Klose KE. Lipidation of the FPI protein IglE contributes to Francisella tularensis ssp. novicida intramacrophage replication and virulence. Pathog Dis 2014; 72:10-8; PMID:24616435; http://dx.doi.org/10.1111/2049-632X.12167 PubMed DOI PMC
Bröms JE, Lavander M, Meyer L, Sjöstedt A. IglG and IglI of the Francisella pathogenicity island are important virulence determinants of Francisella tularensis LVS. Infect Immun 2011; 79:3683-3696; PMID:21690239; http://dx.doi.org/10.1128/IAI.01344-10 PubMed DOI PMC
Bröms JE, Meyer L, Sjöstedt A. A mutagenesis-based approach identifies amino acids in the N-terminal part of Francisella tularensis IglE that critically control Type VI system-mediated secretion. Virulence 2017:1-27; http://dx.doi.org/10.1080/21505594.2016.1258507 PubMed DOI PMC
Hare RF, Hueffer K. Francisella novicida pathogenicity island encoded proteins were secreted during infection of macrophage-like cells. PLoS One 2014; 9:e105773; PMID:25158041; http://dx.doi.org/10.1371/journal.pone.0105773 PubMed DOI PMC
Breaking the cellular defense: the role of autophagy evasion in Francisella virulence
Bacteriophage SPO1 protein Gp46 suppresses functions of HU protein in Francisella tularensis
Innate Immune Recognition: An Issue More Complex Than Expected
