Comparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity
Language English Country Netherlands Media print-electronic
Document type Comparative Study, Journal Article
PubMed
28390706
DOI
10.1016/j.mimet.2017.04.003
PII: S0167-7012(17)30088-X
Knihovny.cz E-resources
- Keywords
- Carbapenems, Enterobacteriaceae, GES, IMP, Pseudomonas aeruginosa, VIM,
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacterial Proteins analysis metabolism MeSH
- Bacteriological Techniques methods MeSH
- beta-Lactamases analysis metabolism MeSH
- Enterobacteriaceae drug effects enzymology MeSH
- Imipenem pharmacology MeSH
- Carbapenems pharmacology MeSH
- Meropenem MeSH
- Microbial Sensitivity Tests MeSH
- Pseudomonas aeruginosa drug effects enzymology MeSH
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods MeSH
- Thienamycins pharmacokinetics MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Bacterial Proteins MeSH
- beta-Lactamases MeSH
- carbapenemase MeSH Browser
- Imipenem MeSH
- Carbapenems MeSH
- Meropenem MeSH
- Thienamycins MeSH
A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae.
References provided by Crossref.org
Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals
Carbapenemase-Producing Gram-Negative Bacteria from American Crows in the United States
Detection of Five mcr-9-Carrying Enterobacterales Isolates in Four Czech Hospitals
Genomic Insight of VIM-harboring IncA Plasmid from a Clinical ST69 Escherichia coli Strain in Italy
Characterization of NDM-Encoding Plasmids From Enterobacteriaceae Recovered From Czech Hospitals
