Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review
- Keywords
- Acetylcholinesterase, catalytic bioscavengers, identification, methods of detection, nerve agents, organophosphate, reactivators,
- MeSH
- Acetylcholinesterase drug effects metabolism MeSH
- Antidotes pharmacology MeSH
- Chemical Warfare Agents poisoning MeSH
- Cholinesterase Inhibitors poisoning MeSH
- Humans MeSH
- Organophosphorus Compounds antagonists & inhibitors toxicity MeSH
- Organophosphate Poisoning drug therapy physiopathology MeSH
- Patents as Topic MeSH
- Drug Design MeSH
- Cholinesterase Reactivators pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Antidotes MeSH
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- Organophosphorus Compounds MeSH
- Cholinesterase Reactivators MeSH
organophosphorus compounds act as irreversible inhibitors of the vital enzyme acetylcholinesterase (AChE). this leads in the accumulation of acetylcholine (ACh) leading to cholinergic crisis and death. The main therapeutic approach is based on immediate administration of an ache reactivator as an antidote enabling recovery of the ache function. Areas covered: This review covers the development of AChE reactivators in order to introduce a new efficient drug that will overcome significant failures of common antidotes. Further options together with methods of detection are also discussed in order to assure a complete insight into the treatment of intoxication. Expert opinion: Since organophosphates belong to the most toxic chemical warfare agents, efficient antidotes are a matter of importance. The solution of how to limit the basic drawbacks of clinically used reactivators remained a spotlight for many researches worldwide. Recent strategies of the treatment of OP exposure bring us new possibilities which may overcome classic antidotes. The importance of detection of OP also has to be taken into consideration. Especially, with the fast spreading toxic effect when death can occur within minutes.
References provided by Crossref.org
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019)
