Hyaluronan hydrogels modified by glycinated Kraft lignin: Morphology, swelling, viscoelastic properties and biocompatibility
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
29253988
DOI
10.1016/j.carbpol.2017.10.048
PII: S0144-8617(17)31191-8
Knihovny.cz E-resources
- Keywords
- Biocompatibility of hydrogels, Hyaluronan, Hydrogel, Lignin, Mechanical properties, Swelling behaviour,
- MeSH
- Biocompatible Materials chemistry MeSH
- Glycine chemistry MeSH
- Hydrogels chemistry MeSH
- Kinetics MeSH
- Hyaluronic Acid chemistry MeSH
- Lignin chemistry MeSH
- Porosity MeSH
- Elasticity MeSH
- Cross-Linking Reagents chemistry MeSH
- Solubility MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Viscosity MeSH
- Water chemistry MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Glycine MeSH
- Hydrogels MeSH
- Kraft lignin MeSH Browser
- Hyaluronic Acid MeSH
- Lignin MeSH
- Cross-Linking Reagents MeSH
- Water MeSH
Effects of the addition of water soluble glycinated Kraft lignin (WS/KL) on the mechanical stability and biocompatibility of hyaluronan (NaHy) hydrogels were evaluated in this work. Water soluble lignin was obtained by the modification of Kraft lignin via a Mannich reaction. It was found that WS/KL is highly compatible with hyaluronan due to its improved water solubility, which favours its use in designing new advanced composite hydrogels. The effects of the concentration of WS/KL on morphological, swelling and creep/recovery behaviours of hyaluronan hydrogels were investigated. It was detected that the creep resistance and creep recovery of NaHy hydrogels was improved by the incorporation of up to 3% (w/w) of WS/KL. In contrast, the swelling capacity of hydrogels was decreased. The cytotoxicity tests proved that glycinated KL lignin limits the viability of cells only slightly, and the final hyaluronan/lignin hydrogels were non-toxic materials.
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