Effects of the addition of water soluble glycinated Kraft lignin (WS/KL) on the mechanical stability and biocompatibility of hyaluronan (NaHy) hydrogels were evaluated in this work. Water soluble lignin was obtained by the modification of Kraft lignin via a Mannich reaction. It was found that WS/KL is highly compatible with hyaluronan due to its improved water solubility, which favours its use in designing new advanced composite hydrogels. The effects of the concentration of WS/KL on morphological, swelling and creep/recovery behaviours of hyaluronan hydrogels were investigated. It was detected that the creep resistance and creep recovery of NaHy hydrogels was improved by the incorporation of up to 3% (w/w) of WS/KL. In contrast, the swelling capacity of hydrogels was decreased. The cytotoxicity tests proved that glycinated KL lignin limits the viability of cells only slightly, and the final hyaluronan/lignin hydrogels were non-toxic materials.

Centre of Polymer Systems Tomas Bata University in Zlín třída Tomáše Bati 5678 760 01 Zlín Czech Republic

Centre of Polymer Systems Tomas Bata University in Zlín třída Tomáše Bati 5678 760 01 Zlín Czech Republic; Department of Physics and Materials Engineering Faculty of Technology Tomas Bata University in Zlín nám T G Masaryka 275 760 01 Zlín Czech Republic

Department of Chemistry Faculty of Technology Tomas Bata University in Zlín nám T G Masaryka 275 760 01 Zlín Czech Republic

Institute for Chemistry and Technology of Materials Graz University of Technology Stremayrgasse 9 8010 Graz Austria; Department of Food Chemistry and Biotechnology Faculty of Chemistry Brno University of Technology Purkynova 118 612 00 Brno Czech Republic

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