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PubMed

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Molecular markers in well-differentiated thyroid cancer

D'Cruz, Anil K
Author D'Cruz, Anil K Head Neck Services, Tata Memorial Hospital, Parel, Mumbai, 400012, India. docdcruz@gmail.com
Vaish, Richa
Author Vaish, Richa Head Neck Services, Tata Memorial Hospital, Parel, Mumbai, 400012, India
Vaidya, Abhishek
Author Vaidya, Abhishek National Cancer Institute, Nagpur, India NKPSIMS, Nagpur, India
Nixon, Iain J
Author Nixon, Iain J Departments of Surgery and Otolaryngology, Head and Neck Surgery, Edinburgh University, Edinburgh, UK
Williams, Michelle D
Author Williams, Michelle D Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Vander Poorten, Vincent
Author Vander Poorten, Vincent Otorhinolaryngology-Head and Neck Surgery and Department of Oncology, Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium
López, Fernando
Author López, Fernando Department of Otolaryngology, Hospital Universitario Central de Asturias, IUOPA, University of Oviedo, CIBERONC, Oviedo, Spain
Angelos, Peter
Author Angelos, Peter Department of Surgery and Surgical Ethics, The University of Chicago Medicine, Chicago, IL, USA
Shaha, Ashok R
Author Shaha, Ashok R Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Khafif, Avi
Author Khafif, Avi Head and Neck Surgery and Oncology Unit, A.R.M. Center for Advanced Otolaryngology Head and Neck Surgery, Assuta Medical Center, Tel Aviv, Israel
Skalova, Alena
Author Skalova, Alena Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, Czech Republic
Rinaldo, Alessandra
Author Rinaldo, Alessandra University of Udine School of Medicine, Padua, Italy
Hunt, Jennifer L
Author Hunt, Jennifer L Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Ferlito, Alfio
Author Ferlito, Alfio International Head and Neck Scientific Group, Padua, Italy

European archives of oto-rhino-laryngology. 2018 Jun ; 275 (6) : 1375-1384. [epub] 20180406

Eur Arch Otorhinolaryngol
ISSN 1434-4726 | 0937-4477
Source

Language English Country Germany Media print-electronic

Document type Journal Article, Review

Persistent link https://www.medvik.cz/link/pmid29626249

PubMed 29626249
DOI 10.1007/s00405-018-4944-1
PII: 10.1007/s00405-018-4944-1
Knihovny.cz E-resources

Keywords
Adenocarcinoma, follicular, Carcinoma, papillary, NIFTP, Thyroid neoplasm/diagnosis, Thyroid neoplasm/genetics, miRNA,
MeSH
Biomarkers metabolism MeSH
Carcinoma genetics metabolism pathology MeSH
Humans MeSH
Mutation genetics MeSH
Thyroid Neoplasms genetics metabolism pathology MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH
Review MeSH
Names of Substances
Biomarkers MeSH

PURPOSE: Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. This review covers the fundamental role of the signaling pathways and genetic changes involved in thyroid carcinogenesis. The current literature on the prognostic significance of these markers is also described. METHODS: PubMed was used to search relevant articles. The key terms "thyroid nodules", "thyroid cancer papillary", "carcinoma papillary follicular", "carcinoma papillary", "adenocarcinoma follicular" were searched in MeSH, and "molecular markers", "molecular testing", mutation, BRAF, RAS, RET/PTC, PAX 8, miRNA, NIFTP in title and abstract fields. Multiple combinations were done and a group of experts in the subject from the International Head and Neck Scientific Group extracted the relevant articles and formulated the review. RESULTS: There has been considerable progress in the understanding of thyroid carcinogenesis and the emergence of numerous molecular markers in the recent years with potential to be used in the diagnostic algorithm of these nodules. However, their precise role in routine clinical practice continues to be a contentious issue. Majority of the studies in this context are retrospective and impact of these mutations is not independent of other prognostic factors making the interpretation difficult. CONCLUSION: The prevalence of these mutations in thyroid nodule is high and it is a continuously evolving field. Clinicians should stay informed as recommendation on the use of these markers is expected to evolve.

Department of Otolaryngology Hospital Universitario Central de Asturias IUOPA University of Oviedo CIBERONC Oviedo Spain

Department of Pathology Charles University Faculty of Medicine in Plzen Plzen Czech Republic

Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX USA

Department of Pathology University of Arkansas for Medical Sciences Little Rock AR USA

Department of Surgery and Surgical Ethics The University of Chicago Medicine Chicago IL USA

Departments of Surgery and Otolaryngology Head and Neck Surgery Edinburgh University Edinburgh UK

Head and Neck Service Memorial Sloan Kettering Cancer Center New York NY USA

Head and Neck Surgery and Oncology Unit A R M Center for Advanced Otolaryngology Head and Neck Surgery Assuta Medical Center Tel Aviv Israel

Head Neck Services Tata Memorial Hospital Parel Mumbai 400012 India

International Head and Neck Scientific Group Padua Italy

National Cancer Institute Nagpur India

NKPSIMS Nagpur India