We summarize current knowledge regarding regulatory functions of long noncoding RNAs (lncRNAs) in yeast, with emphasis on lncRNAs identified recently in yeast colonies and biofilms. Potential regulatory functions of these lncRNAs in differentiated cells of domesticated colonies adapted to plentiful conditions versus yeast colony biofilms are discussed. We show that specific cell types differ in their complements of lncRNA, that this complement changes over time in differentiating upper cells, and that these lncRNAs target diverse functional categories of genes in different cell subpopulations and specific colony types.

Department Medical Genetics Oslo University Hospital and University of Oslo 0450 Oslo Norway

Faculty of Science Charles University BIOCEV 252 50 Vestec Czech Republic

Institute of Microbiology of the Czech Academy of Sciences BIOCEV 252 50 Vestec Czech Republic

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Non-Coding RNAs: Regulators of Stress, Ageing, and Developmental Decisions in Yeast?