Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid-sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH(4)(+) shuttle between tumor and healthy metazoan cells.

Department of Genetics and Microbiology Faculty of Science Charles University Prague Prague Czech Republic

Citace poskytuje Crossref.org

Differential stability of Gcn4p controls its cell-specific activity in differentiated yeast colonies

Non-Coding RNAs: Regulators of Stress, Ageing, and Developmental Decisions in Yeast?

The characteristics of differentiated yeast subpopulations depend on their lifestyle and available nutrients

Spatially structured yeast communities: Understanding structure formation and regulation with omics tools

Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

The Whi2p-Psr1p/Psr2p complex regulates interference competition and expansion of cells with competitive advantage in yeast colonies

Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops

Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae

Anaerobic peroxisomes in Mastigamoeba balamuthi

Long Noncoding RNAs in Yeast Cells and Differentiated Subpopulations of Yeast Colonies and Biofilms

Transcriptome Remodeling of Differentiated Cells during Chronological Ageing of Yeast Colonies: New Insights into Metabolic Differentiation

Metabolic differentiation of surface and invasive cells of yeast colony biofilms revealed by gene expression profiling

Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis

Mitochondria in aging cell differentiation

Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality

Divergent branches of mitochondrial signaling regulate specific genes and the viability of specialized cell types of differentiated yeast colonies

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Longevity of U cells of differentiated yeast colonies grown on respiratory medium depends on active glycolysis

Global changes in gene expression associated with phenotypic switching of wild yeast

Zobrazit více v PubMed

GEO
GSE35887