Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
55005623
Howard Hughes Medical Institute - United States
PubMed
22560924
DOI
10.1016/j.molcel.2012.04.001
PII: S1097-2765(12)00266-3
Knihovny.cz E-resources
- MeSH
- Amino Acids metabolism MeSH
- Autophagy MeSH
- Models, Biological MeSH
- Cell Division MeSH
- Stress, Physiological MeSH
- Gene Knockout Techniques MeSH
- Genes, Fungal MeSH
- Quaternary Ammonium Compounds metabolism MeSH
- Humans MeSH
- Metabolic Networks and Pathways MeSH
- Neoplasms metabolism pathology MeSH
- Saccharomyces cerevisiae Proteins genetics MeSH
- Saccharomyces cerevisiae cytology genetics growth & development metabolism MeSH
- Signal Transduction MeSH
- Oxygen Consumption MeSH
- Transcriptome MeSH
- Amino Acid Transport Systems genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amino Acids MeSH
- Quaternary Ammonium Compounds MeSH
- Saccharomyces cerevisiae Proteins MeSH
- Amino Acid Transport Systems MeSH
Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid-sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH(4)(+) shuttle between tumor and healthy metazoan cells.
References provided by Crossref.org
Differential stability of Gcn4p controls its cell-specific activity in differentiated yeast colonies
Non-Coding RNAs: Regulators of Stress, Ageing, and Developmental Decisions in Yeast?
Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Cell Distribution within Yeast Colonies and Colony Biofilms: How Structure Develops
Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae
Anaerobic peroxisomes in Mastigamoeba balamuthi
Long Noncoding RNAs in Yeast Cells and Differentiated Subpopulations of Yeast Colonies and Biofilms
Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis
Mitochondria in aging cell differentiation
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
GEO
GSE35887
