The phosphatidic acid paradox: Too many actions for one molecule class? Lessons from plants
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29842906
DOI
10.1016/j.plipres.2018.05.003
PII: S0163-7827(18)30018-3
Knihovny.cz E-resources
- Keywords
- Diacylglycerol kinase, Hormonal regulation, Membrane, Phosphatidic acid, Phospholipase D, Stress response,
- MeSH
- Plant Physiological Phenomena * MeSH
- Phosphatidic Acids chemistry metabolism MeSH
- Molecular Structure MeSH
- Plant Proteins genetics metabolism MeSH
- Plants chemistry genetics metabolism MeSH
- Amino Acid Sequence MeSH
- Signal Transduction * MeSH
- Protein Binding MeSH
- Binding Sites genetics MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Phosphatidic Acids MeSH
- Plant Proteins MeSH
Phosphatidic acid (PA) is a simple phospholipid observed in most organisms. PA acts as a key metabolic intermediate and a second messenger that regulates many cell activities. In plants, PA is involved in numerous cell responses induced by hormones, stress inputs and developmental processes. Interestingly, PA production can be triggered by opposite stressors, such as cold and heat, or by hormones that are considered to be antagonistic, such as abscisic acid and salicylic acid. This property questions the specificity of the responses controlled by PA. Are there generic responses to PA, meaning that cell regulation triggered by PA would be always the same, even in opposite physiological situations? Alternatively, do the responses to PA differ according to the physiological context within the cells? If so, the mechanisms that regulate the divergence of PA-controlled reactions are poorly defined. This review summarizes the latest opinions on how PA signalling is directed in plant cells and examines the intrinsic properties of PA that enable its regulatory diversity. We propose a concept whereby PA regulatory messages are perceived as complex "signatures" that take into account their production site, the availability of target proteins and the relevant cellular environments.
References provided by Crossref.org
DIACYLGLYCEROL KINASE 5 participates in flagellin-induced signaling in Arabidopsis
Phosphatidic Acid in Plant Hormonal Signaling: From Target Proteins to Membrane Conformations
Phospholipase Dα1 Acts as a Negative Regulator of High Mg2+-Induced Leaf Senescence in Arabidopsis
