Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
30118763
DOI
10.1016/j.vph.2018.08.008
PII: S1537-1891(18)30124-1
Knihovny.cz E-zdroje
- Klíčová slova
- Blood pressure, Flavonoid, Metabolite, Phenolic, Vascular,
- MeSH
- antihypertenziva farmakologie MeSH
- aorta thoracica účinky léků MeSH
- arteriae mesentericae účinky léků MeSH
- arteriální tlak účinky léků MeSH
- hypertenze farmakoterapie patofyziologie MeSH
- katecholy farmakologie MeSH
- kyselina 3,4-dihydroxyfenyloctová farmakologie MeSH
- modely nemocí na zvířatech MeSH
- potkani inbrední SHR MeSH
- potkani Wistar MeSH
- techniky in vitro MeSH
- vazodilatace účinky léků MeSH
- vazodilatancia farmakologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 4-methylcatechol MeSH Prohlížeč
- antihypertenziva MeSH
- katecholy MeSH
- kyselina 3,4-dihydroxyfenyloctová MeSH
- vazodilatancia MeSH
SCOPE: The flavonoid quercetin reduces arterial blood pressure in animals and humans but the mechanisms remains elusive. The aim of this study was to test the activity of flavonoid microbial metabolites, which can participate on the final vasorelaxant effect. METHODS AND RESULTS: Both ex vivo (isolated rat thoracic aorta and mesenteric artery) and in vivo (normotensive and spontaneously hypertensive rats) approaches were used in this study. 4-methylcatechol and 3,4-dihydroxyphenylacetic acid (DHPA) had greater vasorelaxant effects on mesenteric artery than 3-(3-hydroxyphenyl)propionic acid, the previously reported metabolite with vasorelaxant effect. In vivo testing confirmed their blood pressure decreasing effect given both as bolus and slow infusion. Their mechanism at molecular level was different. CONCLUSIONS: This study is the first to show that flavonoid metabolites DHPA and 4-methylcatechol decrease arterial blood pressure and hence a mixture of microbial metabolites formed in the gastrointestinal tract may be responsible for or contribute to the effect of orally ingested quercetin.
Department of Analytical Chemistry Charles University Hradec Králové Czech Republic
Department of Biological and Medical Sciences Charles University Hradec Králové Czech Republic
Department of Pharmacology and Toxicology Charles University Hradec Králové Czech Republic
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