Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30118763
DOI
10.1016/j.vph.2018.08.008
PII: S1537-1891(18)30124-1
Knihovny.cz E-resources
- Keywords
- Blood pressure, Flavonoid, Metabolite, Phenolic, Vascular,
- MeSH
- Antihypertensive Agents pharmacology MeSH
- Aorta, Thoracic drug effects MeSH
- Mesenteric Arteries drug effects MeSH
- Arterial Pressure drug effects MeSH
- Hypertension drug therapy physiopathology MeSH
- Catechols pharmacology MeSH
- 3,4-Dihydroxyphenylacetic Acid pharmacology MeSH
- Disease Models, Animal MeSH
- Rats, Inbred SHR MeSH
- Rats, Wistar MeSH
- In Vitro Techniques MeSH
- Vasodilation drug effects MeSH
- Vasodilator Agents pharmacology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 4-methylcatechol MeSH Browser
- Antihypertensive Agents MeSH
- Catechols MeSH
- 3,4-Dihydroxyphenylacetic Acid MeSH
- Vasodilator Agents MeSH
SCOPE: The flavonoid quercetin reduces arterial blood pressure in animals and humans but the mechanisms remains elusive. The aim of this study was to test the activity of flavonoid microbial metabolites, which can participate on the final vasorelaxant effect. METHODS AND RESULTS: Both ex vivo (isolated rat thoracic aorta and mesenteric artery) and in vivo (normotensive and spontaneously hypertensive rats) approaches were used in this study. 4-methylcatechol and 3,4-dihydroxyphenylacetic acid (DHPA) had greater vasorelaxant effects on mesenteric artery than 3-(3-hydroxyphenyl)propionic acid, the previously reported metabolite with vasorelaxant effect. In vivo testing confirmed their blood pressure decreasing effect given both as bolus and slow infusion. Their mechanism at molecular level was different. CONCLUSIONS: This study is the first to show that flavonoid metabolites DHPA and 4-methylcatechol decrease arterial blood pressure and hence a mixture of microbial metabolites formed in the gastrointestinal tract may be responsible for or contribute to the effect of orally ingested quercetin.
Department of Analytical Chemistry Charles University Hradec Králové Czech Republic
Department of Biological and Medical Sciences Charles University Hradec Králové Czech Republic
Department of Pharmacology and Toxicology Charles University Hradec Králové Czech Republic
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