Cercarial dermatitis (CD) is an allergic skin disease that rises in consequence of infection by invasive stages (cercariae) of trematodes of the family Schistosomatidae. CD has been considered a re-emerging disease, human cases have been reported from all continents, and tourism-threatening outbreaks occur even in frequented recreational areas. Although the symptoms of CD are generally known, the data on immune response in human patients are sporadic and incomprehensive. In the present study, we attempted to correlate the symptoms, personal history, and time course of CD in human patients with differential cell counts, dynamics of selected cytokines, and dynamics and quality of antibody response. By a systematic follow-up, we obtained a uniquely complex dataset from ten persons accidentally and concurrently infected by the same parasite species in the same locality. The onset of CD was significantly faster, and the symptoms were heavier in participants with a history of CD if compared to naive ones, who, however, also developed some of the symptoms. The repeatedly infected persons had elevated proportion of eosinophils 1 week post exposure (p.e.) and a stronger specific IgG but not IgM response, whereas specific IgE response was not observed. Increased serum levels of IL-4 occurred 1 and 3 week(s) p.e. in all participants. There was high variability in individual immunoblot patterns of IgG response, and no antigen with a universal diagnostic potential was confirmed. The presented analyses suggested that a complex approach can improve the accuracy of the diagnosis of CD, but component data should be interpreted carefully.

Department of Parasitology Faculty of Science Charles University Viničná 7 12844 Prague 2 Czech Republic

Institute of Immunology and Microbiology 1st Faculty of Medicine Charles University and General University Hospital Prague Studničkova 7 12800 Prague 2 Czech Republic

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Nat Rev Immunol. 2018 Jan;18(1):62-76 PubMed

Prim Care. 2016 Dec;43(4):607-617 PubMed

Nat Rev Immunol. 2017 Dec;17(12):746-760 PubMed

Trends Parasitol. 2001 Feb;17(2):66-9 PubMed

J Parasitol Res. 2012;2012:761968 PubMed

Int J Parasitol. 2015 Mar;45(4):215-24 PubMed

Parasitol Res. 2008 Jun;103(1):51-8 PubMed

J Immunol. 2000 Jun 15;164(12):6406-16 PubMed

Am J Hyg. 1949 May;49(3):290-302 PubMed

Int J Hyg Environ Health. 2016 Oct;219(7 Pt B):693-699 PubMed

Infect Immun. 2006 Apr;74(4):2169-76 PubMed

Clin Microbiol Infect. 2010 Mar;16(3):225-31 PubMed

PLoS One. 2017 Mar 15;12(3):e0173217 PubMed

Clin Exp Immunol. 1998 Sep;113(3):317-9 PubMed

Vector Borne Zoonotic Dis. 2017 Mar;17(3):190-194 PubMed

Annu Rev Immunol. 2001;19:683-765 PubMed

Parasitol Res. 2002 Jun;88(6):513-21 PubMed

J Immunol. 2004 Mar 1;172(5):3157-66 PubMed

Science. 1994 Jun 24;264(5167):1876-7 PubMed

Parasitol Res. 1998 Oct;84(10):787-95 PubMed

Exp Parasitol. 1996 Nov;84(2):295-9 PubMed

PLoS Negl Trop Dis. 2016 Feb 10;10(2):e0004406 PubMed

Clin Microbiol Rev. 2015 Jan;28(1):165-90 PubMed

J Helminthol. 1999 Sep;73(3):215-20 PubMed

Parasite Immunol. 2008 Nov-Dec;30(11-12):585-95 PubMed

J Parasitol. 1953 Jun;39(3):237-46 PubMed

Trends Parasitol. 2013 Feb;29(2):65-74 PubMed

Adv Parasitol. 2002;52:155-233 PubMed

Parasite. 2008 Sep;15(3):299-303 PubMed

Parasitol Res. 2009 Oct;105(4):1061-6 PubMed

Clin Rev Allergy Immunol. 2013 Aug;45(1):63-74 PubMed

Parasite Immunol. 2016 Feb;38(2):81-92 PubMed

Dermatologica. 1953;107(5):302-41 PubMed

Parasitol Res. 2007 May;100(6):1243-7 PubMed

Parasitology. 1998 Feb;116 ( Pt 2):139-47 PubMed

Am J Pathol. 1976 Sep;84(3):479-500 PubMed

Am J Hyg. 1949 Sep;50(2):152-67 PubMed

Ther Umsch. 2017 Nov;74(6):297-300 PubMed

Parasit Vectors. 2011 Aug 19;4:162 PubMed

PLoS Pathog. 2011 Mar;7(3):e1001323 PubMed

Parasit Vectors. 2014 Jun 19;7:277 PubMed

Parasit Vectors. 2015 Jul 28;8:400 PubMed

J Helminthol. 2010 Sep;84(3):327-35 PubMed

Indian J Dermatol. 2017 Jan-Feb;62(1):66-78 PubMed

Parasitol Int. 2012 Jun;61(2):250-9 PubMed

PLoS One. 2016 Feb 19;11(2):e0149678 PubMed

J Immunol. 2004 Mar 15;172(6):3766-74 PubMed

Parasitology. 2002 Mar;124(Pt 3):307-13 PubMed

Parasitol Res. 2016 Aug;115(8):3049-56 PubMed

Parasitol Res. 2007 Jun;101(1):91-7 PubMed

Parasitol Res. 2016 Mar;115(3):1027-37 PubMed

J Immunol. 1989 Jun 15;142(12):4422-7 PubMed

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