Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide. Despite the clinical long-term and near-term benefits of lowering cholesterol in, respectively, primary and secondary prevention of ASCVD, cholesterol levels remain under-treated, with many patients not achieving their recommended targets. The present article will review the latest updates on lipid management with emphases on the different classes of cholesterol-lowering agents and their clinical uses.

1st Department of Internal Medicine Comenius University and University Hospital Mickiewiczova 2247 13 811 07 Bratislava Slovakia

2nd Department of Surgery Faculty of Medicine St Anne's University Hospital and Masaryk University Brno Czech Republic

Department of Biology Jessenius Faculty of Medicine in Martin Comenius Universityin Bratislava Martin Slovakia

Department of Cardiology The Adelaide and Meath Hospital Dublin Incorporating the National Children Hospital Tallaght Hospital Tallaght Dublin 24 Ireland

Department of Clinical Medicine Education Division School of Medicine Trinity College Dublin Dublin Ireland

Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania

Department of General Medicine Faculty of Medicine Slovak Medical University Bratislava Slovakia

Department of Internal Medicine Brothers of Mercy Hospital Polni 3 63900 Brno Czech Republic

Department of Nutrition Faculty of Nursing and Professional Health Studies Slovak Medical University Limbova 12 833 03 Bratislava Slovakia

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