Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, přehledy
PubMed
30907588
DOI
10.1021/acs.jafc.9b00694
Knihovny.cz E-zdroje
- Klíčová slova
- ABC transporters, cancer, flavonoids, flavonolignans, glucose transporters, methicillin resistant Staphylococcus aureus (MRSA), multidrug resistance (MDR),
- MeSH
- ABC transportéry antagonisté a inhibitory genetika metabolismus MeSH
- antibakteriální látky farmakologie MeSH
- antitumorózní látky terapeutické užití MeSH
- Bacteria genetika metabolismus MeSH
- bakteriální infekce farmakoterapie mikrobiologie MeSH
- bakteriální léková rezistence * MeSH
- bakteriální proteiny antagonisté a inhibitory genetika metabolismus MeSH
- chemorezistence * MeSH
- flavonoidy aplikace a dávkování MeSH
- flavonolignany aplikace a dávkování MeSH
- lidé MeSH
- nádory farmakoterapie genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- ABC transportéry MeSH
- antibakteriální látky MeSH
- antitumorózní látky MeSH
- bakteriální proteiny MeSH
- flavonoidy MeSH
- flavonolignany MeSH
Multidrug resistance (MDR) is a major challenge for the 21th century in both cancer chemotherapy and antibiotic treatment of bacterial infections. Efflux pumps and transport proteins play an important role in MDR. Compounds displaying inhibitory activity toward these proteins are prospective for adjuvant treatment of such conditions. Natural low-cost and nontoxic flavonoids, thanks to their vast structural diversity, offer a great pool of lead structures with broad possibility of chemical derivatizations. Various flavonoids were found to reverse both antineoplastic and bacterial multidrug resistance by inhibiting Adenosine triphosphate Binding Cassette (ABC)-transporters (human P-glycoprotein, multidrug resistance-associated protein MRP-1, breast cancer resistance protein, and bacterial ABC transporters), as well as other bacterial drug efflux pumps: major facilitator superfamily (MFS), multidrug and toxic compound extrusion (MATE), small multidrug resistance (SMR) and resistance-nodulation-cell-division (RND) transporters, and glucose transporters. Flavonoids and particularly flavonolignans are therefore highly prospective compounds for defying multidrug resistance.
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