Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans
Language English Country United States Media print-electronic
Document type Journal Article, Review
- Keywords
- ABC transporters, cancer, flavonoids, flavonolignans, glucose transporters, methicillin resistant Staphylococcus aureus (MRSA), multidrug resistance (MDR),
- MeSH
- ATP-Binding Cassette Transporters antagonists & inhibitors genetics metabolism MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacteria genetics metabolism MeSH
- Bacterial Infections drug therapy microbiology MeSH
- Drug Resistance, Bacterial * MeSH
- Bacterial Proteins antagonists & inhibitors genetics metabolism MeSH
- Drug Resistance, Neoplasm * MeSH
- Flavonoids administration & dosage MeSH
- Flavonolignans administration & dosage MeSH
- Humans MeSH
- Neoplasms drug therapy genetics metabolism MeSH
- Antineoplastic Agents therapeutic use MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- ATP-Binding Cassette Transporters MeSH
- Anti-Bacterial Agents MeSH
- Bacterial Proteins MeSH
- Flavonoids MeSH
- Flavonolignans MeSH
- Antineoplastic Agents MeSH
Multidrug resistance (MDR) is a major challenge for the 21th century in both cancer chemotherapy and antibiotic treatment of bacterial infections. Efflux pumps and transport proteins play an important role in MDR. Compounds displaying inhibitory activity toward these proteins are prospective for adjuvant treatment of such conditions. Natural low-cost and nontoxic flavonoids, thanks to their vast structural diversity, offer a great pool of lead structures with broad possibility of chemical derivatizations. Various flavonoids were found to reverse both antineoplastic and bacterial multidrug resistance by inhibiting Adenosine triphosphate Binding Cassette (ABC)-transporters (human P-glycoprotein, multidrug resistance-associated protein MRP-1, breast cancer resistance protein, and bacterial ABC transporters), as well as other bacterial drug efflux pumps: major facilitator superfamily (MFS), multidrug and toxic compound extrusion (MATE), small multidrug resistance (SMR) and resistance-nodulation-cell-division (RND) transporters, and glucose transporters. Flavonoids and particularly flavonolignans are therefore highly prospective compounds for defying multidrug resistance.
References provided by Crossref.org
Nitrogen-Containing Flavonoids-Preparation and Biological Activity
Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
