Helminth Therapy - From the Parasite Perspective
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
31153721
DOI
10.1016/j.pt.2019.04.009
PII: S1471-4922(19)30085-6
Knihovny.cz E-zdroje
- Klíčová slova
- Biome Depletion Theory, Hymenolepis diminuta, Necator americanus, Old Friends Hypothesis, Trichuris suis ova, helminth therapy,
- MeSH
- analýza nákladů a výnosů MeSH
- chronická nemoc terapie MeSH
- cizopasní červi imunologie MeSH
- lidé MeSH
- zánět parazitologie terapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Studies in animal models and humans suggest that intentional exposure to helminths or helminth-derived products may hold promise for treating chronic inflammatory-associated diseases (CIADs). Although the mechanisms underlying 'helminth therapy' are being evaluated, little attention has been paid to the actual organisms in use. Here we examine the notion that, because of the complexity of biological symbiosis, intact helminths rather than helminth-derived products are likely to prove more useful for clinical purposes. Further, weighing potential cost/benefit ratios of various helminths along with other factors, such as feasibility of production, we argue that the four helminths currently in use for CIAD treatments in humans were selected more by happenstance than by design, and that other candidates not yet tested may prove superior.
Citace poskytuje Crossref.org
Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect
Capsid Structure of Leishmania RNA Virus 1
