Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
31261031
DOI
10.1016/j.phytochem.2019.112055
PII: S0031-9422(19)30197-9
Knihovny.cz E-resources
- Keywords
- Alkaloids, Alzheimer's disease, Amaryllidaceae, Cholinesterase inhibition, Glycogen synthase kinase-3β inhibition, Narcimatuline, Narcissus pseudonarcissus L. cv. Dutch master, Prolyl oligopeptidase,
- MeSH
- Acetylcholinesterase metabolism MeSH
- Amaryllidaceae Alkaloids chemistry isolation & purification pharmacology MeSH
- Alzheimer Disease drug therapy metabolism MeSH
- Butyrylcholinesterase metabolism MeSH
- Cholinesterase Inhibitors chemistry isolation & purification pharmacology MeSH
- Glycogen Synthase Kinase 3 beta antagonists & inhibitors metabolism MeSH
- Humans MeSH
- Molecular Structure MeSH
- Narcissus chemistry MeSH
- Neuroprotective Agents chemistry isolation & purification pharmacology MeSH
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases metabolism MeSH
- Dose-Response Relationship, Drug MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Amaryllidaceae Alkaloids MeSH
- Butyrylcholinesterase MeSH
- Cholinesterase Inhibitors MeSH
- Glycogen Synthase Kinase 3 beta MeSH
- Neuroprotective Agents MeSH
- PREPL protein, human MeSH Browser
- Prolyl Oligopeptidases MeSH
- Serine Endopeptidases MeSH
Twenty-one known Amaryllidaceae alkaloids of various structural types and one undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of Narcissus pseudonarcissus L. cv. Dutch Master. The chemical structures were elucidated by combination of MS, HRMS, 1D and 2D NMR spectroscopic techniques, and by comparison with literature data. Narcimatuline amalgamates two basic scaffolds of Amaryllidaceae alkaloids in its core, namely galanthamine and galanthindole. All isolated compounds were evaluated for their in vitro acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), prolyl oligopeptidase (POP), and glycogen synthase kinase-3β (GSK-3β) inhibitory activities. The most interesting biological profile was demonstrated by newly isolated alkaloid narcimatuline.
References provided by Crossref.org
Chemistry and Biological Activity of Alkaloids from the Genus Lycoris (Amaryllidaceae)
The Genus Nerine Herb. (Amaryllidaceae): Ethnobotany, Phytochemistry, and Biological Activity
