Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
31261031
DOI
10.1016/j.phytochem.2019.112055
PII: S0031-9422(19)30197-9
Knihovny.cz E-zdroje
- Klíčová slova
- Alkaloids, Alzheimer's disease, Amaryllidaceae, Cholinesterase inhibition, Glycogen synthase kinase-3β inhibition, Narcimatuline, Narcissus pseudonarcissus L. cv. Dutch master, Prolyl oligopeptidase,
- MeSH
- acetylcholinesterasa metabolismus MeSH
- alkaloidy amarylkovitých chemie izolace a purifikace farmakologie MeSH
- Alzheimerova nemoc farmakoterapie metabolismus MeSH
- butyrylcholinesterasa metabolismus MeSH
- cholinesterasové inhibitory chemie izolace a purifikace farmakologie MeSH
- GSK3B antagonisté a inhibitory metabolismus MeSH
- lidé MeSH
- molekulární struktura MeSH
- Narcissus chemie MeSH
- neuroprotektivní látky chemie izolace a purifikace farmakologie MeSH
- prolyloligopeptidasy MeSH
- serinové endopeptidasy metabolismus MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcholinesterasa MeSH
- alkaloidy amarylkovitých MeSH
- butyrylcholinesterasa MeSH
- cholinesterasové inhibitory MeSH
- GSK3B MeSH
- neuroprotektivní látky MeSH
- PREPL protein, human MeSH Prohlížeč
- prolyloligopeptidasy MeSH
- serinové endopeptidasy MeSH
Twenty-one known Amaryllidaceae alkaloids of various structural types and one undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of Narcissus pseudonarcissus L. cv. Dutch Master. The chemical structures were elucidated by combination of MS, HRMS, 1D and 2D NMR spectroscopic techniques, and by comparison with literature data. Narcimatuline amalgamates two basic scaffolds of Amaryllidaceae alkaloids in its core, namely galanthamine and galanthindole. All isolated compounds were evaluated for their in vitro acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), prolyl oligopeptidase (POP), and glycogen synthase kinase-3β (GSK-3β) inhibitory activities. The most interesting biological profile was demonstrated by newly isolated alkaloid narcimatuline.
Citace poskytuje Crossref.org
Chemistry and Biological Activity of Alkaloids from the Genus Lycoris (Amaryllidaceae)
The Genus Nerine Herb. (Amaryllidaceae): Ethnobotany, Phytochemistry, and Biological Activity
