Small protease inhibitors in tick saliva and salivary glands and their role in tick-host-pathogen interactions
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31816416
DOI
10.1016/j.bbapap.2019.140336
PII: S1570-9639(19)30221-3
Knihovny.cz E-resources
- Keywords
- Cystatins, Kunitz-domain proteins, Protease inhibitor, Saliva, Salivary gland, Sialomes, Tick-host-pathogen,
- MeSH
- Aprotinin chemistry metabolism MeSH
- Cystatins chemistry metabolism MeSH
- Protease Inhibitors metabolism MeSH
- Host-Parasite Interactions * MeSH
- Ticks MeSH
- Proteomics MeSH
- Salivary Glands metabolism MeSH
- Saliva metabolism MeSH
- Transcriptome MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Aprotinin MeSH
- Cystatins MeSH
- Protease Inhibitors MeSH
Ticks must durably suppress vertebrate host responses (hemostasis, inflammation, immunity) to avoid rejection and act as vectors of many pathogenic microorganisms that cause disease in humans and animals. Transcriptomics and proteomics studies have been used to study tick-host-pathogen interactions and have facilitated the systematic characterization of salivary composition and molecular dynamics throughout tick feeding. Tick saliva contains a complement of protease inhibitors that are differentially produced during feeding, many of which inhibit blood coagulation, platelet aggregation, vasodilation, and immunity. Here we focus on two major groups of protease inhibitors, the small molecular weight Kunitz inhibitors and cystatins. We discuss their role in tick-host-pathogen interactions, how they mediate the interaction between ticks and their hosts, and how they might be exploited both by pathogens to invade hosts and as candidates for the treatment of various human pathologies.
References provided by Crossref.org
Serpins in Tick Physiology and Tick-Host Interaction
Insights into the Role of Tick Salivary Protease Inhibitors during Ectoparasite-Host Crosstalk
