Porcine model for the study of sperm capacitation, fertilization and male fertility
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, přehledy
Grantová podpora
2015-67015-23231
National Institute of Food and Agriculture
2019-67012-29714
National Institute of Food and Agriculture
5 R01 HD084353-02
Foundation for the National Institutes of Health
Food for the 21st Century Program
University of Missouri
CZ.1.05/1.1.00/02.0109
European Regional Development Fund
GA-18-11275S
Grantová Agentura České Republiky
RVO: 86652036
Institute of Biotechnology, Czech Academy of Sciences
INTER-COST LTC 18059
Ministerstvo Školství, Mládeže a Tělovýchovy
CIGA20182006
Internal Grant Agency of the Czech University of Life Sciences Prague
PubMed
32140927
DOI
10.1007/s00441-020-03181-1
PII: 10.1007/s00441-020-03181-1
Knihovny.cz E-zdroje
- Klíčová slova
- Capacitation, Fertilization, Male fertility, Pig, Zona pellucida,
- MeSH
- fertilita fyziologie MeSH
- fertilizace fyziologie MeSH
- kapacitace spermií fyziologie MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- prasata MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Mammalian fertilization remains a poorly understood event with the vast majority of studies done in the mouse model. The purpose of this review is to revise the current knowledge about semen deposition, sperm transport, sperm capacitation, gamete interactions and early embryonic development with a focus on the porcine model as a relevant, alternative model organism to humans. The review provides a thorough overview of post-ejaculation events inside the sow's reproductive tract including comparisons with humans and implications for human fertilization and assisted reproductive therapy (ART). Porcine methodology for sperm handling, preservation, in vitro capacitation, oocyte in vitro maturation, in vitro fertilization and intra-cytoplasmic sperm injection that are routinely used in pig research laboratories can be successfully translated into ART to treat human infertility. Last, but not least, new knowledge about mitochondrial inheritance in the pig can provide an insight into human mitochondrial diseases and new knowledge on polyspermy defense mechanisms could contribute to the development of new male contraceptives.
Department of Obstetrics Gynecology and Women's Health University of Missouri Columbia MO 65211 USA
Division of Animal Sciences University of Missouri Columbia MO 65211 USA
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