Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
32320720
DOI
10.1016/j.ijpharm.2020.119318
PII: S0378-5173(20)30302-1
Knihovny.cz E-zdroje
- Klíčová slova
- Blood immune cells, Curcumin, Diplacone, Glucan particles, Immunomodulatory effect, Inflammation,
- MeSH
- antiflogistika chemie farmakologie MeSH
- beta-glukany chemie izolace a purifikace farmakologie MeSH
- flavanony chemie farmakologie MeSH
- imunologické faktory chemie izolace a purifikace farmakologie MeSH
- interleukin-1beta metabolismus MeSH
- kultivované buňky MeSH
- kurkumin chemie farmakologie MeSH
- leukocyty mononukleární účinky léků imunologie metabolismus MeSH
- neutrofily účinky léků imunologie metabolismus MeSH
- nosiče léků * MeSH
- příprava léků MeSH
- proteoglykany MeSH
- respirační vzplanutí účinky léků MeSH
- rozpouštědla chemie MeSH
- Saccharomyces cerevisiae chemie MeSH
- Sus scrofa MeSH
- TNF-alfa metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antiflogistika MeSH
- beta-glukany MeSH
- diplacone MeSH Prohlížeč
- flavanony MeSH
- imunologické faktory MeSH
- interleukin-1beta MeSH
- kurkumin MeSH
- nosiče léků * MeSH
- polysaccharide-K MeSH Prohlížeč
- proteoglykany MeSH
- rozpouštědla MeSH
- TNF-alfa MeSH
Natural compounds offer a wide spectrum of potential active substances, but often they have a poor bioavailability. To increase the bioavailability and bioactivity of the natural anti-inflammatory molecules curcumin and diplacone, we used glucan particles (GPs), hollow shells from Saccharomyces cerevisiae composed mainly of β-1,3-d-glucan. Their indigestibility and relative stability in the gut combined with their immunomodulatory effects makes them promising carriers for such compounds. This study aimed to determine how curcumin and diplacone, either alone or incorporated in GPs, affect the immunomodulatory activity of the latter by assessing the respiratory burst response and the secretion of pro-inflammatory cytokines by primary porcine innate immune cells. Incorporating curcumin and diplacone into GPs by controlled evaporation of the organic solvent substantially reduced the respiratory burst response mediated by GPs. Incorporated curcumin in GPs also reduced GPs mediated secretion of IL-1β and TNF-α by innate immune cells. The obtained results indicate a potentially beneficial effect of the incorporation of curcumin or diplacone into GPs against inflammation.
Department of Analytical Chemistry University of Chemistry and Technology Prague Czech Republic
Department of Chemical Engineering University of Chemistry and Technology Prague Czech Republic
Department of Immunology Veterinary Research Institute Brno Czech Republic
Citace poskytuje Crossref.org
