PURPOSE: The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. METHODS: This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. RESULTS AND CONCLUSION: Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.

1st Department of Internal Medicine Faculty of Medicine Comenius University and University Hospital Bratislava Slovakia

2nd Department of Surgery Faculty of Medicine Masaryk University Pekarska 53 656 91 Brno Czech Republic

Biomedical Center Martin Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Martin Slovakia

Clinic of Obstetrics and Gynecology Jessenius Faculty of Medicine Comenius University in Bratislava Martin Slovakia

Department of Biology and Ecology Faculty of Education Catholic University in Ruzomberok Ruzomberok Slovakia

Department of Histology and Embryology Jessenius Faculty of Medicine Comenius University Martin Slovakia

Department of Medical Biology Jessenius Faculty of Medicine Comenius University in Bratislava 036 01 Martin Slovakia

Department of Natural Drugs Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Brno Czech Republic

Department of Physiology and Biophysics Weill Cornell Medicine in Qatar Education City Qatar Foundation Doha 24144 Qatar

Department of Thoracic Surgery Faculty of Medicine and Dentistry Medical University of Silesia Katowice Poland

Faculty of Medicine University of Oviedo Central University Hospital of Asturias Oviedo Spain

Gastroenterology Unit Department of Medicine Azienda Ospedaliera Universitaria Integrata Policlinico GB Rossi University of Verona Verona Italy

Lambda Life JSC Bratislava Slovakia

St Anne's University Hospital Brno Czech Republic

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