Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33534179
DOI
10.1002/ijc.33475
Knihovny.cz E-zdroje
- Klíčová slova
- association study, long noncoding RNA, pancreatic cancer, single nucleotide polymorphism,
- MeSH
- celogenomová asociační studie MeSH
- duktální karcinom slinivky břišní genetika MeSH
- genetická predispozice k nemoci MeSH
- inhibitor p15 cyklin-dependentní kinasy genetika MeSH
- jednonukleotidový polymorfismus * MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikro RNA genetika MeSH
- nádory slinivky břišní genetika MeSH
- RNA dlouhá nekódující genetika MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- výpočetní biologie metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- CDKN2B protein, human MeSH Prohlížeč
- inhibitor p15 cyklin-dependentní kinasy MeSH
- mikro RNA MeSH
- MIRN1256 microRNA, human MeSH Prohlížeč
- RNA dlouhá nekódující MeSH
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 × 10-9 ). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.
1st Department of Medicine University of Szeged Szeged Hungary
ARC NET Centre for Applied Research on Cancer University and Hospital Trust of Verona Verona Italy
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Center of Gastroenterology Fundeni Clinical Institute Bucharest Romania
Department of Biology University of Pisa Pisa Italy
Department of Diagnostics and Public Health Section of pathology University of Verona Verona Italy
Department of Digestive Tract Diseases Medical University of Lodz Lodz Poland
Department of Gastroenterology IRCCS Humanitas Research Hospital Endoscopic Unit Milan Italy
Department of General Surgery University of Heidelberg Heidelberg Germany
Department of Hematology Institute of Hematology and Transfusion Medicine Warsaw Poland
Department of Surgery Oncology and Gastroenterology DiSCOG University of Padova Padova Italy
Division of Preventive Oncology German Cancer Research Center Heidelberg Germany
Gastroenterology San Carlo Hospital Potenza Italy
Genomic Epidemiology Group German Cancer Research Center Heidelberg Germany
German Cancer Consortium Heidelberg Germany
Institute for Translational Medicine Medical School University of Pécs Pécs Hungary
Institute of Biology and Medical Genetics 1st Medical Faculty Prague Czech Republic
Institute of Experimental Medicine Czech Academy of Sciences Prague Czech Republic
Sant'Andrea Hospital Faculty of Medicine and Psychology Sapienza University of Rome Rome Italy
Szent György University Teaching Hospital of Fejér County Székesfehérvár Hungary
UO Chirurgia Generale e dei Trapianti Università di Pisa Pisa Italy
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