Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
36075844
DOI
10.1016/j.pt.2022.08.010
PII: S1471-4922(22)00187-8
Knihovny.cz E-resources
- Keywords
- Trypanosoma, assembly factor, biogenesis, mitochondrial ribosomes, mitoribosomes,
- MeSH
- Cryoelectron Microscopy MeSH
- Mitochondrial Ribosomes * chemistry metabolism MeSH
- Mitochondria metabolism MeSH
- RNA, Ribosomal * analysis chemistry metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- RNA, Ribosomal * MeSH
Translation in mitochondria is mediated by mitochondrial ribosomes, or mitoribosomes, complex ribonucleoprotein machines with dual genetic origin. Mitoribosomes in trypanosomatid parasites diverged markedly from their bacterial ancestors and other eukaryotic lineages in terms of protein composition, rRNA content, and overall architecture, yet their core functional elements remained conserved. Recent cryo-electron microscopy studies provided atomic models of trypanosomatid large and small mitoribosomal subunits and their precursors, making these parasites the organisms with the best-understood biogenesis of mitoribosomes. The structures revealed molecular mechanisms and players involved in the assembly of mitoribosomes not only in the parasites, but also in eukaryotes in general.
References provided by Crossref.org
Mettl15-Mettl17 modulates the transition from early to late pre-mitoribosome
