Simulation of Complex Biomolecular Systems: The Ribosome Challenge
Language English Country United States Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
- Keywords
- antibiotics, computer simulations, cryo-EM, cryogenic electron microscopy, molecular dynamics, ribosome, translation,
- MeSH
- Computer Simulation MeSH
- Ribosomes * MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied by computer simulations. Pushing the limits of length- and timescales that can be accessed by current hard- and software has expanded the ability to describe biomolecules at different levels of detail. We focus in this review on the ribosome, which exemplifies the close interplay between experiment and various simulation approaches, as a particularly challenging and prototypic nanomachine that is pivotal to cellular biology due to its central role in translation. We sketch widely used simulation methods and demonstrate how the combination of simulations and experiments advances our understanding of the function of the translation apparatus based on fundamental physics.
References provided by Crossref.org
Acceleration of Molecular Simulations by Parametric Time-Lagged tSNE Metadynamics
