Visualizing and analyzing 3D biomolecular structures using Mol* at RCSB.org: Influenza A H5N1 virus proteome case study
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
Grantová podpora
DBI-2019297
National Science Foundation
DBI-2129634
National Science Foundation
DBI-2321666
National Science Foundation
22-30571M
Czech Science Foundation
DE-SC0019749
U.S. Department of Energy
BB/V004247/1
Biotechnology and Biological Sciences Research Council - United Kingdom
BB/W017970/1
Biotechnology and Biological Sciences Research Council - United Kingdom
R01GM152779
NIH HHS - United States
PubMed
40099807
PubMed Central
PMC11915458
DOI
10.1002/pro.70093
Knihovny.cz E-zdroje
- Klíčová slova
- 3D biostructure, Protein Data Bank, global health, influenza A H5N1 virus, molecular visualization, open‐source, pandemic preparedness, viral pathogen, virus life cycle, web‐based,
- MeSH
- databáze proteinů MeSH
- internet MeSH
- konformace proteinů MeSH
- molekulární modely MeSH
- proteom * chemie MeSH
- software * MeSH
- virové proteiny * chemie MeSH
- virus chřipky A, podtyp H5N1 * chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- proteom * MeSH
- virové proteiny * MeSH
The easiest and often most useful way to work with experimentally determined or computationally predicted structures of biomolecules is by viewing their three-dimensional (3D) shapes using a molecular visualization tool. Mol* was collaboratively developed by RCSB Protein Data Bank (RCSB PDB, RCSB.org) and Protein Data Bank in Europe (PDBe, PDBe.org) as an open-source, web-based, 3D visualization software suite for examination and analyses of biostructures. It is capable of displaying atomic coordinates and related experimental data of biomolecular structures together with a variety of annotations, facilitating basic and applied research, training, education, and information dissemination. Across RCSB.org, the RCSB PDB research-focused web portal, Mol* has been implemented to support single-mouse-click atomic-level visualization of biomolecules (e.g., proteins, nucleic acids, carbohydrates) with bound cofactors, small-molecule ligands, ions, water molecules, or other macromolecules. RCSB.org Mol* can seamlessly display 3D structures from various sources, allowing structure interrogation, superimposition, and comparison. Using influenza A H5N1 virus as a topical case study of an important pathogen, we exemplify how Mol* has been embedded within various RCSB.org tools-allowing users to view polymer sequence and structure-based annotations integrated from trusted bioinformatics data resources, assess patterns and trends in groups of structures, and view structures of any size and compositional complexity. In addition to being linked to every experimentally determined biostructure and Computed Structure Model made available at RCSB.org, Standalone Mol* is freely available for visualizing any atomic-level or multi-scale biostructure at rcsb.org/3d-view.
Mol* Consortium San Diego California USA
National Centre for Biomolecular Research Faculty of Science Masaryk University Brno Czech Republic
Rutgers Cancer Institute Rutgers The State University of New Jersey New Brunswick New Jersey USA
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