The easiest and often most useful way to work with experimentally determined or computationally predicted structures of biomolecules is by viewing their three-dimensional (3D) shapes using a molecular visualization tool. Mol* was collaboratively developed by RCSB Protein Data Bank (RCSB PDB, RCSB.org) and Protein Data Bank in Europe (PDBe, PDBe.org) as an open-source, web-based, 3D visualization software suite for examination and analyses of biostructures. It is capable of displaying atomic coordinates and related experimental data of biomolecular structures together with a variety of annotations, facilitating basic and applied research, training, education, and information dissemination. Across RCSB.org, the RCSB PDB research-focused web portal, Mol* has been implemented to support single-mouse-click atomic-level visualization of biomolecules (e.g., proteins, nucleic acids, carbohydrates) with bound cofactors, small-molecule ligands, ions, water molecules, or other macromolecules. RCSB.org Mol* can seamlessly display 3D structures from various sources, allowing structure interrogation, superimposition, and comparison. Using influenza A H5N1 virus as a topical case study of an important pathogen, we exemplify how Mol* has been embedded within various RCSB.org tools-allowing users to view polymer sequence and structure-based annotations integrated from trusted bioinformatics data resources, assess patterns and trends in groups of structures, and view structures of any size and compositional complexity. In addition to being linked to every experimentally determined biostructure and Computed Structure Model made available at RCSB.org, Standalone Mol* is freely available for visualizing any atomic-level or multi-scale biostructure at rcsb.org/3d-view.

Department of Chemistry and Chemical Biology Rutgers The State University of New Jersey Piscataway New Jersey USA

Department of Integrative Structural and Computational Biology The Scripps Research Institute La Jolla California USA

Mol* Consortium San Diego California USA

National Centre for Biomolecular Research Faculty of Science Masaryk University Brno Czech Republic

Research Collaboratory for Structural Bioinformatics Protein Data Bank Institute for Quantitative Biomedicine Rutgers The State University of New Jersey Piscataway New Jersey USA

Research Collaboratory for Structural Bioinformatics Protein Data Bank San Diego Supercomputer Center University of California San Diego La Jolla California USA

Rutgers Artificial Intelligence and Data Science Collaboratory Rutgers The State University of New Jersey Piscataway New Jersey USA

Rutgers Cancer Institute Rutgers The State University of New Jersey New Brunswick New Jersey USA

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