MutL Proteins [MutL proteiny]

topical
Terms

homolog MutL
homology MutL
MutL homolog

 

MutL Homologs

Persistent link   https://www.medvik.cz/link/D000070956
Definition

DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.

DUI
D000070956 MeSH Browser
CUI
M000612744
RN
EC 3.6.1.3
Previous indexing
Adenosine Triphosphatases (1992-2016); DNA Repair (1982-2016)
History note
2017
Public note
2017

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
EC
economics 0
GE
genetics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 0
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.074 DNA Repair Enzymes 60
D08.811.074.062 AlkB Enzymes
D08.811.074.124 Deoxyribodipyrimidine Photo-Lyase 1
D08.811.074.249 DNA Glycosylases 18
D08.811.074.500 DNA Ligases 6
D08.811.074.750 DNA-(Apurinic or Apyrimidinic Site) Lyase 9
D08.811.074.766 MutL Proteins
D08.811.074.766.250 Mismatch Repair Endonuclease PMS2 8
D08.811.074.766.500 MutL Protein Homolog 1 17
D08.811.074.844 MutS Proteins
D08.811.074.875 Polynucleotide 5'-Hydroxyl-Kinase 2
D08.811.277 Hydrolases 475
D08.811.277.040 Acid Anhydride Hydrolases 6
D08.811.277.040.025 Adenosine Triphosphatases 429
D08.811.277.040.025.024 ATPases Associated with Diverse Cellular Activities 8
D08.811.277.040.025.047 Arsenite Transporting ATPases
D08.811.277.040.025.095 Ca(2+) Mg(2+)-ATPase 18
D08.811.277.040.025.142 Chaperonins 7
D08.811.277.040.025.159 DNA Helicases 63
D08.811.277.040.025.176 Mi-2 Nucleosome Remodeling and Deacetylase Complex 2
D08.811.277.040.025.193 Molecular Motor Proteins 11
D08.811.277.040.025.215 MutL Proteins
D08.811.277.040.025.215.250 Mismatch Repair Endonuclease PMS2 8
D08.811.277.040.025.215.500 MutL Protein Homolog 1 17
D08.811.277.040.025.292 MutS Proteins
D08.811.277.040.025.314 P-type ATPases
D08.811.277.040.025.325 Proton-Translocating ATPases 28
D08.811.277.040.025.494 SecA Proteins 2
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.260 DNA-Binding Proteins 553
D12.776.260.060 Adenovirus E2 Proteins 1
D12.776.260.103 Basic Helix-Loop-Helix Transcription Factors 61
D12.776.260.108 Basic-Leucine Zipper Transcription Factors 18
D12.776.260.114 Butyrate Response Factor 1
D12.776.260.120 CCCTC-Binding Factor 2
D12.776.260.123 Centromere Protein A 2
D12.776.260.125 Centromere Protein B
D12.776.260.158 Early Growth Response Transcription Factors 1
D12.776.260.197 Elongin
D12.776.260.235 Erythroid-Specific DNA-Binding Factors 1
D12.776.260.246 Factor For Inversion Stimulation Protein
D12.776.260.254 G-Box Binding Factors
D12.776.260.257 GATA Transcription Factors 2
D12.776.260.260 Heat Shock Transcription Factors 1
D12.776.260.262 Hepatocyte Nuclear Factors 5
D12.776.260.268 Heterogeneous-Nuclear Ribonucleoprotein K
D12.776.260.312 HMGA Proteins 1
D12.776.260.356 HMGB Proteins 4
D12.776.260.400 Homeodomain Proteins 122
D12.776.260.420 I-kappa B Proteins 5
D12.776.260.457 Immunoglobulin J Recombination Signal Sequence-Binding Protein
D12.776.260.495 Integration Host Factors
D12.776.260.504 Interferon Regulatory Factors 11
D12.776.260.513 Interferon-Stimulated Gene Factor 3
D12.776.260.522 Kruppel-Like Transcription Factors 26
D12.776.260.525 Ku Autoantigen 5
D12.776.260.527 Leucine-Responsive Regulatory Protein
D12.776.260.529 LIM-Homeodomain Proteins 5
D12.776.260.531 Liver X Receptors 5
D12.776.260.532 Matrix Attachment Region Binding Proteins 9
D12.776.260.534 MDS1 and EVI1 Complex Locus Protein 2
D12.776.260.536 Methyl-CpG-Binding Protein 2 12
D12.776.260.538 Minichromosome Maintenance 1 Protein 1
D12.776.260.539 MRE11 Homologue Protein 6
D12.776.260.540 MutL Proteins
D12.776.260.540.250 Mismatch Repair Endonuclease PMS2 8
D12.776.260.540.500 MutL Protein Homolog 1 17
D12.776.260.556 MutS Proteins
D12.776.260.560 Myeloid-Lymphoid Leukemia Protein 39
D12.776.260.600 NF-kappa B 209
D12.776.260.605 NFI Transcription Factors 6
D12.776.260.615 Nuclear Respiratory Factors
D12.776.260.623 Nucleobindins 2
D12.776.260.630 Oncogene Protein p55(v-myc) 1
D12.776.260.640 Origin Recognition Complex 1
D12.776.260.643 Orphan Nuclear Receptors 2
D12.776.260.645 Paired Box Transcription Factors 21
D12.776.260.650 Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4
D12.776.260.655 POU Domain Factors 4
D12.776.260.660 Proto-Oncogene Proteins c-bcl-6 3
D12.776.260.665 Proto-Oncogene Proteins c-ets 19
D12.776.260.675 Proto-Oncogene Proteins c-myb 30
D12.776.260.682 Proto-Oncogene Proteins c-rel 2
D12.776.260.690 Proto-Oncogene Proteins c-sis 3
D12.776.260.693 PTB-Associated Splicing Factor
D12.776.260.695 Rad51 Recombinase 42
D12.776.260.696 Rad52 DNA Repair and Recombination Protein 9
D12.776.260.700 Replication Protein A 12
D12.776.260.702 Replication Protein C 3
D12.776.260.703 Repressor Proteins 189
D12.776.260.704 Retinoblastoma Protein 52
D12.776.260.713 Smad Proteins 14
D12.776.260.716 SMARCB1 Protein 15
D12.776.260.719 SOX Transcription Factors 1
D12.776.260.725 T-Box Domain Proteins 14
D12.776.260.730 TCF Transcription Factors 3
D12.776.260.733 TEA Domain Transcription Factors 3
D12.776.260.735 Telomere-Binding Proteins 24
D12.776.260.750 Toll-Like Receptor 9 15
D12.776.260.755 Trans-Activators 110
D12.776.260.760 Transcription Factor AP-2 1
D12.776.260.768 Transcription Factor MTF-1
D12.776.260.775 Transcription Factors, General 1
D12.776.260.790 Tristetraprolin 2
D12.776.260.805 Tumor Suppressor p53-Binding Protein 1 16
D12.776.260.820 Tumor Suppressor Protein p53 754
D12.776.260.885 Tumor Protein p73 6
D12.776.260.950 Winged-Helix Transcription Factors
D12.776.260.963 X-ray Repair Cross Complementing Protein 1 9
D12.776.260.975 Xeroderma Pigmentosum Group A Protein 2

Add

Narrower terms