Tuberous Sclerosis Complex 1 Protein [hamartin]

topical
7
Terms

protein hamartin
protein komplexu tuberózní sklerózy 1

 

Hamartin

Persistent link   https://www.medvik.cz/link/D000077004
Definition

An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.

DUI
D000077004 MeSH Browser
CUI
M0279212
History note
2019 (1997)
Public note
2019; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2006-2018 and under PROTEINS 1997-2005

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 7
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 383
D12.644.360 Intracellular Signaling Peptides and Proteins 175
D12.644.360.011 Activating Transcription Factor 6 3
D12.644.360.024 Adaptor Proteins, Signal Transducing 182
D12.644.360.075 Apoptosis Regulatory Proteins 79
D12.644.360.087 Calcineurin 76
D12.644.360.138 Circadian Rhythm Signaling Peptides and Proteins 11
D12.644.360.175 Cold Shock Proteins and Peptides 3
D12.644.360.225 Cyclin-Dependent Kinase Inhibitor Proteins 44
D12.644.360.262 Cyclins 112
D12.644.360.265 Disks Large Homolog 4 Protein 1
D12.644.360.325 GTP-Binding Protein Regulators 16
D12.644.360.365 I-kappa B Proteins 5
D12.644.360.368 Inhibitor of Growth Protein 1
D12.644.360.372 Intracellular Calcium-Sensing Proteins 2
D12.644.360.410 Mesothelin 2
D12.644.360.420 Methyl-Accepting Chemotaxis Proteins
D12.644.360.534 Mucin-4 5
D12.644.360.537 Myristoylated Alanine-Rich C Kinase Substrate
D12.644.360.539 NLR Proteins 5
D12.644.360.543 Olfactory Marker Protein
D12.644.360.562 Phosphatidylethanolamine Binding Protein
D12.644.360.606 Protein Phosphatase Inhibitory Proteins
D12.644.360.650 RNA-Binding Protein EWS 15
D12.644.360.700 SAP90-PSD95 Associated Proteins
D12.644.360.813 Secreted Frizzled-Related Proteins
D12.644.360.925 Tuberous Sclerosis Complex 1 Protein 7
D12.644.360.938 Tuberous Sclerosis Complex 2 Protein 10
D12.644.360.950 Tumor Necrosis Factor alpha-Induced Protein 3 2
D12.644.360.963 Tumor Protein, Translationally-Controlled 1
D12.776 Proteins 2 579
D12.776.476 Intracellular Signaling Peptides and Proteins 175
D12.776.476.008 3',5'-Cyclic-AMP Phosphodiesterases 12
D12.776.476.009 3',5'-Cyclic-GMP Phosphodiesterases 2
D12.776.476.011 Activating Transcription Factor 6 3
D12.776.476.024 Adaptor Proteins, Signal Transducing 182
D12.776.476.050 Adenylyl Cyclases 160
D12.776.476.075 Apoptosis Regulatory Proteins 79
D12.776.476.081 Axin Signaling Complex 1
D12.776.476.156 Circadian Rhythm Signaling Peptides and Proteins 11
D12.776.476.175 Cold Shock Proteins and Peptides 3
D12.776.476.225 Cyclin-Dependent Kinase Inhibitor Proteins 44
D12.776.476.262 Cyclins 112
D12.776.476.265 Disks Large Homolog 4 Protein 1
D12.776.476.325 GTP-Binding Protein Regulators 16
D12.776.476.338 GTP-Binding Proteins 117
D12.776.476.350 Guanylate Cyclase 30
D12.776.476.381 I-kappa B Proteins 5
D12.776.476.383 Inhibitor of Growth Protein 1
D12.776.476.387 Intracellular Calcium-Sensing Proteins 2
D12.776.476.410 Mesothelin 2
D12.776.476.420 Methyl-Accepting Chemotaxis Proteins
D12.776.476.445 Mitogen-Activated Protein Kinase Phosphatases 1
D12.776.476.534 Mucin-4 5
D12.776.476.539 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.476.543 Olfactory Marker Protein
D12.776.476.555 Phosphatidylethanolamine Binding Protein
D12.776.476.556 Phosphatidylinositol 3-Kinases 126
D12.776.476.557 Phosphoinositide Phospholipase C 2
D12.776.476.559 Phosphoprotein Phosphatases 23
D12.776.476.561 Protein Phosphatase Inhibitory Proteins
D12.776.476.563 Protein Serine-Threonine Kinases 273
D12.776.476.564 Protein Tyrosine Phosphatases 27
D12.776.476.568 Protein-Tyrosine Kinases 622
D12.776.476.590 PTEN Phosphohydrolase 50
D12.776.476.650 RNA-Binding Protein EWS 15
D12.776.476.700 SAP90-PSD95 Associated Proteins
D12.776.476.800 Secreted Frizzled-Related Proteins
D12.776.476.900 Sirtuins 20
D12.776.476.932 Tuberous Sclerosis Complex 1 Protein 7
D12.776.476.935 Tuberous Sclerosis Complex 2 Protein 10
D12.776.476.938 Tumor Necrosis Factor alpha-Induced Protein 3 2
D12.776.476.941 Tumor Protein, Translationally-Controlled 1
D12.776.624 Neoplasm Proteins 413
D12.776.624.776 Tumor Suppressor Proteins 269
D12.776.624.776.010 Adenomatous Polyposis Coli Protein 13
D12.776.624.776.021 DCC Receptor
D12.776.624.776.051 Fanconi Anemia Complementation Group N Protein 4
D12.776.624.776.100 BRCA1 Protein 103
D12.776.624.776.101 BRCA2 Protein 97
D12.776.624.776.355 Cyclin-Dependent Kinase Inhibitor Proteins 44
D12.776.624.776.418 Cystatin M
D12.776.624.776.482 Deubiquitinating Enzyme CYLD 1
D12.776.624.776.503 Inhibitor of Growth Protein 1
D12.776.624.776.523 Kangai-1 Protein 1
D12.776.624.776.546 Kisspeptins 6
D12.776.624.776.610 Neurofibromin 1 14
D12.776.624.776.612 Neurofibromin 2 3
D12.776.624.776.633 Patched Receptors
D12.776.624.776.654 Promyelocytic Leukemia Protein 4
D12.776.624.776.695 PTEN Phosphohydrolase 50
D12.776.624.776.717 Retinoblastoma-Like Protein p107 4
D12.776.624.776.735 Retinoblastoma-Like Protein p130 5
D12.776.624.776.745 Retinoblastoma Protein 52
D12.776.624.776.760 Smad4 Protein 7
D12.776.624.776.766 Tuberous Sclerosis Complex 1 Protein 7
D12.776.624.776.769 Tuberous Sclerosis Complex 2 Protein 10
D12.776.624.776.772 Tumor Suppressor Protein p14ARF 4
D12.776.624.776.775 Tumor Suppressor Protein p53 762
D12.776.624.776.820 Tumor Protein p73 6
D12.776.624.776.865 Von Hippel-Lindau Tumor Suppressor Protein 31
D12.776.624.776.960 WT1 Proteins 30
D12.776.624.776.980 WW Domain-Containing Oxidoreductase 1

TSC1 protein, human Chemical MeSH Browser

Tsc1 protein, mouse Chemical MeSH Browser

Tsc1 protein, rat Chemical MeSH Browser

Back Add