Kininogens [kininogeny]
- Terms
-
kininogen
-
Cystatins, Kininogen
Kininogen
Prekinins
Prokinins
T-Kininogen
Thiostatin
Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
- Annotation
- cysteine proteinase inhib; /drug eff /physiol permitted
- DUI
- D007704 MeSH Browser
- CUI
- M0012050
- Previous indexing
- Proteins (1966-1971); Kinins (1966-1971)
- History note
- 74(72)
- Public note
- 74
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis 2
- AI
- antagonists & inhibitors 1
- BI
- biosynthesis 1
- BL
- blood 3
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 1
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 1
- PK
- pharmacokinetics
- PD
- pharmacology 1
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects 1
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UR
- urine
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