TNF-alfa [Tumor Necrosis Factor-alpha]

tematický
1 303
Termíny

kachektin
TNF-α
tumor nekrotizující faktor alfa

 

Cachectin
Cachectin-Tumor Necrosis Factor
TNF Superfamily, Member 2
TNF-alpha
TNFalpha
Tumor Necrosis Factor
Tumor Necrosis Factor Ligand Superfamily Member 2

Perzistentní odkaz   https://www.medvik.cz/link/D014409
Definice

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

DUI
D014409 MeSH Prohlížeč
CUI
M0022150
Předchozí užití
Endotoxins (1975-1987); Glycoproteins (1975-1987); Necrosis (1975-1987)
Historická pozn.
2005(1988)
Veřejná pozn.
2005; see TUMOR NECROSIS FACTOR 1988-2005

Povolená podhesla

AG
agonisté 2
AN
analýza 29
AI
antagonisté a inhibitory 753
AD
aplikace a dávkování 151
BI
biosyntéza 31
CS
chemická syntéza 0
CH
chemie 4
HI
dějiny 1
EC
ekonomika 11
PK
farmakokinetika 61
PD
farmakologie 91
PH
fyziologie 18
GE
genetika 71
IM
imunologie 69
IP
izolace a purifikace 14
CL
klasifikace 7
BL
krev 73
ME
metabolismus 112
UR
moč 1
CF
mozkomíšní mok 0
DF
nedostatek 1
ST
normy 0
PO
otrava 0
AE
škodlivé účinky 138
TU
terapeutické užití 346
TO
toxicita 2
DE
účinky léků 47
RE
účinky záření 1
UL
ultrastruktura 0
SD
zásobování a distribuce 0

D Chemikálie a léčiva
D09 sacharidy 723
D09.400 glykokonjugáty 58
D09.400.430 glykoproteiny 637
D09.400.430.250 aktiviny 3
D09.400.430.500 proteiny ADAM 14
D09.400.430.563 alfa-1-antichymotrypsin 1
D09.400.430.594 alfa-1-antitrypsin 79
D09.400.430.610 alfa-2-antiplasmin 6
D09.400.430.618 fetuin A 8
D09.400.430.625 antimülleriánský hormon 47
D09.400.430.657 asialoglykoproteiny 5
D09.400.430.673 avidin 14
D09.400.430.681 faktor aktivující B-buňky 37
D09.400.430.685 ligand 4-1BB 1
D09.400.430.687 beta-2-glykoprotein I 14
D09.400.430.688 antigeny CD70
D09.400.430.700 transportní proteiny pro estery cholesterolu 45
D09.400.430.750 klusterin 24
D09.400.430.775 faktory stimulující kolonie 19
D09.400.430.780 inhibiční protein komplementu C1 45
D09.400.430.800 fibriliny
D09.400.430.825 glykované proteiny
D09.400.430.850 glykodelin 1
D09.400.430.860 hemopexin 31
D09.400.430.870 proteiny tepelného šoku HSP47 4
D09.400.430.883 inhibiny 33
D09.400.430.887 laktoferrin 32
D09.400.430.890 membránové glykoproteiny 200
D09.400.430.900 mukoproteiny 77
D09.400.430.910 myelinový P0 protein 8
D09.400.430.912 osteonektin 11
D09.400.430.915 protein C 111
D09.400.430.920 protein S 36
D09.400.430.930 proteoglykany 146
D09.400.430.940 sérový amyloidový protein 32
D09.400.430.950 sialoglykoproteiny 19
D09.400.430.952 thyreoglobulin 155
D09.400.430.955 proteiny vázající thyroxin 38
D09.400.430.960 transkortin 8
D09.400.430.965 TNF-alfa 1 303
D09.400.430.982 vitronektin 7
D09.400.430.998 Zn-alfa-2-glykoprotein
D12 aminokyseliny, peptidy a proteiny 16
D12.644 peptidy 1 380
D12.644.276 mezibuněčné signální peptidy a proteiny 156
D12.644.276.374 cytokiny 2 149
D12.644.276.374.500 monokiny 6
D12.644.276.374.500.400 interleukin-1 119
D12.644.276.374.500.800 TNF-alfa 1 303
D12.644.276.374.750 tumor nekrotizující faktory 371
D12.644.276.374.750.030 antigeny CD70
D12.644.276.374.750.061 faktor aktivující B-buňky 37
D12.644.276.374.750.065 ligand 4-1BB 1
D12.644.276.374.750.092 ligand CD30 2
D12.644.276.374.750.124 ligand CD40 23
D12.644.276.374.750.155 cytokin TWEAK 2
D12.644.276.374.750.186 ektodysplasiny 4
D12.644.276.374.750.249 ligand Fas 18
D12.644.276.374.750.500 lymfotoxin-alfa 17
D12.644.276.374.750.505 lymfotoxin-alfa1, beta2-heterotrimer
D12.644.276.374.750.515 lymfotoxin-beta
D12.644.276.374.750.531 ligand OX40 1
D12.644.276.374.750.562 ligand RANK 142
D12.644.276.374.750.625 protein TRAIL 38
D12.644.276.374.750.626 TNF-alfa 1 303
D12.644.276.374.750.656 protein TALL-2 2
D12.644.276.374.750.690 protein TNFSF14
D12.644.276.374.750.720 ligand TL1
D12.776 proteiny 2 575
D12.776.124 krevní proteiny 909
D12.776.124.050 proteiny akutní fáze 171
D12.776.124.117 beta-2-glykoprotein I 14
D12.776.124.125 koagulační faktory 332
D12.776.124.197 transportní proteiny pro estery cholesterolu 45
D12.776.124.270 fibrin 167
D12.776.124.335 glykované sérové proteiny
D12.776.124.400 hemoglobiny 694
D12.776.124.486 imunoproteiny 14
D12.776.124.625 destičkový růstový faktor 39
D12.776.124.650 protein C 111
D12.776.124.670 protein S 36
D12.776.124.698 plazmatické proteiny vázající retinol 7
D12.776.124.727 sérový albumin 489
D12.776.124.790 sérové globuliny 61
D12.776.124.862 somatomediny 62
D12.776.124.885 proteiny vázající thyroxin 38
D12.776.124.900 TNF-alfa 1 303
D12.776.124.920 vitronektin 7
D12.776.395 glykoproteiny 637
D12.776.395.022 aktiviny 3
D12.776.395.033 proteiny ADAM 14
D12.776.395.045 alfa-1-antichymotrypsin 1
D12.776.395.068 alfa-1-antitrypsin 79
D12.776.395.080 alfa-2-antiplasmin 6
D12.776.395.086 fetuin A 8
D12.776.395.089 antimülleriánský hormon 47
D12.776.395.092 antigeny CD70
D12.776.395.140 asialoglykoproteiny 5
D12.776.395.175 avidin 14
D12.776.395.191 faktor aktivující B-buňky 37
D12.776.395.192 ligand 4-1BB 1
D12.776.395.195 beta-2-glykoprotein I 14
D12.776.395.199 transportní proteiny pro estery cholesterolu 45
D12.776.395.207 klusterin 24
D12.776.395.240 faktory stimulující kolonie 19
D12.776.395.320 inhibiční protein komplementu C1 45
D12.776.395.341 fibriliny
D12.776.395.351 glykované proteiny
D12.776.395.361 glykodelin 1
D12.776.395.401 hemopexin 31
D12.776.395.420 proteiny tepelného šoku HSP47 4
D12.776.395.439 inhibiny 33
D12.776.395.507 laktoferrin 32
D12.776.395.550 membránové glykoproteiny 200
D12.776.395.560 mukoproteiny 77
D12.776.395.570 myelinový P0 protein 8
D12.776.395.600 osteonektin 11
D12.776.395.635 protein C 111
D12.776.395.642 protein S 36
D12.776.395.650 proteoglykany 146
D12.776.395.690 sérový amyloidový protein 32
D12.776.395.700 sialoglykoproteiny 19
D12.776.395.768 thyreoglobulin 155
D12.776.395.832 proteiny vázající thyroxin 38
D12.776.395.901 transkortin 8
D12.776.395.930 TNF-alfa 1 303
D12.776.395.970 vitronektin 7
D12.776.395.985 Zn-alfa-2-glykoprotein
D12.776.467 mezibuněčné signální peptidy a proteiny 156
D12.776.467.374 cytokiny 2 149
D12.776.467.374.500 monokiny 6
D12.776.467.374.500.400 interleukin-1 119
D12.776.467.374.500.800 TNF-alfa 1 303
D12.776.467.374.750 tumor nekrotizující faktory 371
D12.776.467.374.750.030 antigeny CD70
D12.776.467.374.750.061 faktor aktivující B-buňky 37
D12.776.467.374.750.065 ligand 4-1BB 1
D12.776.467.374.750.092 ligand CD30 2
D12.776.467.374.750.124 ligand CD40 23
D12.776.467.374.750.155 cytokin TWEAK 2
D12.776.467.374.750.186 ektodysplasiny 4
D12.776.467.374.750.249 ligand Fas 18
D12.776.467.374.750.500 lymfotoxin-alfa 17
D12.776.467.374.750.505 lymfotoxin-alfa1, beta2-heterotrimer
D12.776.467.374.750.515 lymfotoxin-beta
D12.776.467.374.750.531 ligand OX40 1
D12.776.467.374.750.562 ligand RANK 142
D12.776.467.374.750.625 protein TRAIL 38
D12.776.467.374.750.626 TNF-alfa 1 303
D12.776.467.374.750.656 protein TALL-2 2
D12.776.467.374.750.690 protein TNFSF14
D12.776.467.374.750.710 ligand TL1
D23 biologické faktory 143
D23.529 mezibuněčné signální peptidy a proteiny 156
D23.529.374 cytokiny 2 149
D23.529.374.500 monokiny 6
D23.529.374.500.400 interleukin-1 119
D23.529.374.500.800 TNF-alfa 1 303
D23.529.374.750 tumor nekrotizující faktory 371
D23.529.374.750.030 antigeny CD70
D23.529.374.750.061 faktor aktivující B-buňky 37
D23.529.374.750.065 ligand 4-1BB 1
D23.529.374.750.092 ligand CD30 2
D23.529.374.750.124 ligand CD40 23
D23.529.374.750.155 cytokin TWEAK 2
D23.529.374.750.186 ektodysplasiny 4
D23.529.374.750.249 ligand Fas 18
D23.529.374.750.500 lymfotoxin-alfa 17
D23.529.374.750.505 lymfotoxin-alfa1, beta2-heterotrimer
D23.529.374.750.515 lymfotoxin-beta
D23.529.374.750.531 ligand OX40 1
D23.529.374.750.562 ligand RANK 142
D23.529.374.750.625 protein TRAIL 38
D23.529.374.750.626 TNF-alfa 1 303
D23.529.374.750.656 protein TALL-2 2
D23.529.374.750.690 protein TNFSF14
D23.529.374.750.710 ligand TL1

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