Tumor Necrosis Factor-alpha [TNF-alfa]

topical
1 307
Terms

faktor nádorové nekrózy alfa
kachektin
TNF-α
TNFalfa
tumor nekrotizující faktor alfa

 

Cachectin
Cachectin-Tumor Necrosis Factor
TNF Superfamily, Member 2
TNF-alpha
TNFalpha
Tumor Necrosis Factor
Tumor Necrosis Factor Ligand Superfamily Member 2

Persistent link   https://www.medvik.cz/link/D014409
Definition

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

DUI
D014409 MeSH Browser
CUI
M0022150
Previous indexing
Endotoxins (1975-1987); Glycoproteins (1975-1987); Necrosis (1975-1987)
History note
2005(1988)
Public note
2005; see TUMOR NECROSIS FACTOR 1988-2005

Allowable subheadings

AD
administration & dosage 151
AE
adverse effects 138
AG
agonists 2
AN
analysis 29
AI
antagonists & inhibitors 753
BI
biosynthesis 31
BL
blood 74
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 4
CL
classification 7
DF
deficiency 1
DE
drug effects 47
EC
economics 11
GE
genetics 72
HI
history 1
IM
immunology 69
IP
isolation & purification 14
ME
metabolism 114
PK
pharmacokinetics 61
PD
pharmacology 91
PH
physiology 18
PO
poisoning
RE
radiation effects 1
ST
standards
SD
supply & distribution
TU
therapeutic use 346
TO
toxicity 2
UL
ultrastructure
UR
urine 1

D Chemicals and Drugs
D09 Carbohydrates 723
D09.400 Glycoconjugates 58
D09.400.430 Glycoproteins 637
D09.400.430.250 Activins 3
D09.400.430.500 ADAM Proteins 14
D09.400.430.532 Histidine-Rich Glycoprotein
D09.400.430.563 alpha 1-Antichymotrypsin 1
D09.400.430.594 alpha 1-Antitrypsin 79
D09.400.430.610 alpha-2-Antiplasmin 6
D09.400.430.618 alpha-2-HS-Glycoprotein 8
D09.400.430.625 Anti-Mullerian Hormone 48
D09.400.430.657 Asialoglycoproteins 5
D09.400.430.673 Avidin 14
D09.400.430.681 B-Cell Activating Factor 37
D09.400.430.685 4-1BB Ligand 1
D09.400.430.687 beta 2-Glycoprotein I 14
D09.400.430.688 CD27 Ligand
D09.400.430.700 Cholesterol Ester Transfer Proteins 45
D09.400.430.750 Clusterin 24
D09.400.430.775 Colony-Stimulating Factors 19
D09.400.430.780 Complement C1 Inhibitor Protein 46
D09.400.430.800 Fibrillins
D09.400.430.825 Glycated Proteins
D09.400.430.850 Glycodelin 1
D09.400.430.860 Hemopexin 31
D09.400.430.870 HSP47 Heat-Shock Proteins 4
D09.400.430.883 Inhibins 33
D09.400.430.887 Lactoferrin 32
D09.400.430.890 Membrane Glycoproteins 200
D09.400.430.900 Mucoproteins 77
D09.400.430.910 Myelin P0 Protein 8
D09.400.430.912 Osteonectin 11
D09.400.430.915 Protein C 111
D09.400.430.920 Protein S 36
D09.400.430.930 Proteoglycans 146
D09.400.430.940 Serum Amyloid P-Component 32
D09.400.430.950 Sialoglycoproteins 19
D09.400.430.952 Thyroglobulin 155
D09.400.430.955 Thyroxine-Binding Proteins 38
D09.400.430.960 Transcortin 8
D09.400.430.965 Tumor Necrosis Factor-alpha 1 307
D09.400.430.982 Vitronectin 7
D09.400.430.998 Zn-Alpha-2-Glycoprotein
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 382
D12.644.276 Intercellular Signaling Peptides and Proteins 156
D12.644.276.374 Cytokines 2 154
D12.644.276.374.500 Monokines 6
D12.644.276.374.500.400 Interleukin-1 119
D12.644.276.374.500.800 Tumor Necrosis Factor-alpha 1 307
D12.644.276.374.750 Tumor Necrosis Factors 371
D12.644.276.374.750.030 CD27 Ligand
D12.644.276.374.750.061 B-Cell Activating Factor 37
D12.644.276.374.750.065 4-1BB Ligand 1
D12.644.276.374.750.092 CD30 Ligand 2
D12.644.276.374.750.124 CD40 Ligand 23
D12.644.276.374.750.155 Cytokine TWEAK 2
D12.644.276.374.750.186 Ectodysplasins 4
D12.644.276.374.750.249 Fas Ligand Protein 18
D12.644.276.374.750.500 Lymphotoxin-alpha 17
D12.644.276.374.750.505 Lymphotoxin alpha1, beta2 Heterotrimer
D12.644.276.374.750.515 Lymphotoxin-beta
D12.644.276.374.750.531 OX40 Ligand 1
D12.644.276.374.750.562 RANK Ligand 142
D12.644.276.374.750.625 TNF-Related Apoptosis-Inducing Ligand 38
D12.644.276.374.750.626 Tumor Necrosis Factor-alpha 1 307
D12.644.276.374.750.656 Tumor Necrosis Factor Ligand Superfamily Member 13 2
D12.644.276.374.750.690 Tumor Necrosis Factor Ligand Superfamily Member 14
D12.644.276.374.750.720 Tumor Necrosis Factor Ligand Superfamily Member 15
D12.776 Proteins 2 577
D12.776.124 Blood Proteins 909
D12.776.124.050 Acute-Phase Proteins 171
D12.776.124.117 beta 2-Glycoprotein I 14
D12.776.124.125 Blood Coagulation Factors 332
D12.776.124.197 Cholesterol Ester Transfer Proteins 45
D12.776.124.270 Fibrin 167
D12.776.124.335 Glycated Serum Proteins
D12.776.124.400 Hemoglobins 702
D12.776.124.486 Immunoproteins 14
D12.776.124.625 Platelet-Derived Growth Factor 39
D12.776.124.650 Protein C 111
D12.776.124.670 Protein S 36
D12.776.124.698 Retinol-Binding Proteins, Plasma 8
D12.776.124.727 Serum Albumin 489
D12.776.124.790 Serum Globulins 61
D12.776.124.862 Somatomedins 62
D12.776.124.885 Thyroxine-Binding Proteins 38
D12.776.124.900 Tumor Necrosis Factor-alpha 1 307
D12.776.124.920 Vitronectin 7
D12.776.395 Glycoproteins 637
D12.776.395.022 Activins 3
D12.776.395.033 ADAM Proteins 14
D12.776.395.045 alpha 1-Antichymotrypsin 1
D12.776.395.068 alpha 1-Antitrypsin 79
D12.776.395.080 alpha-2-Antiplasmin 6
D12.776.395.086 alpha-2-HS-Glycoprotein 8
D12.776.395.089 Anti-Mullerian Hormone 48
D12.776.395.092 CD27 Ligand
D12.776.395.140 Asialoglycoproteins 5
D12.776.395.175 Avidin 14
D12.776.395.191 B-Cell Activating Factor 37
D12.776.395.192 4-1BB Ligand 1
D12.776.395.195 beta 2-Glycoprotein I 14
D12.776.395.199 Cholesterol Ester Transfer Proteins 45
D12.776.395.207 Clusterin 24
D12.776.395.240 Colony-Stimulating Factors 19
D12.776.395.320 Complement C1 Inhibitor Protein 46
D12.776.395.341 Fibrillins
D12.776.395.351 Glycated Proteins
D12.776.395.361 Glycodelin 1
D12.776.395.401 Hemopexin 31
D12.776.395.420 HSP47 Heat-Shock Proteins 4
D12.776.395.439 Inhibins 33
D12.776.395.507 Lactoferrin 32
D12.776.395.550 Membrane Glycoproteins 200
D12.776.395.560 Mucoproteins 77
D12.776.395.570 Myelin P0 Protein 8
D12.776.395.600 Osteonectin 11
D12.776.395.635 Protein C 111
D12.776.395.642 Protein S 36
D12.776.395.650 Proteoglycans 146
D12.776.395.690 Serum Amyloid P-Component 32
D12.776.395.700 Sialoglycoproteins 19
D12.776.395.768 Thyroglobulin 155
D12.776.395.832 Thyroxine-Binding Proteins 38
D12.776.395.901 Transcortin 8
D12.776.395.930 Tumor Necrosis Factor-alpha 1 307
D12.776.395.970 Vitronectin 7
D12.776.395.985 Zn-Alpha-2-Glycoprotein
D12.776.467 Intercellular Signaling Peptides and Proteins 156
D12.776.467.374 Cytokines 2 154
D12.776.467.374.500 Monokines 6
D12.776.467.374.500.400 Interleukin-1 119
D12.776.467.374.500.800 Tumor Necrosis Factor-alpha 1 307
D12.776.467.374.750 Tumor Necrosis Factors 371
D12.776.467.374.750.030 CD27 Ligand
D12.776.467.374.750.061 B-Cell Activating Factor 37
D12.776.467.374.750.065 4-1BB Ligand 1
D12.776.467.374.750.092 CD30 Ligand 2
D12.776.467.374.750.124 CD40 Ligand 23
D12.776.467.374.750.155 Cytokine TWEAK 2
D12.776.467.374.750.186 Ectodysplasins 4
D12.776.467.374.750.249 Fas Ligand Protein 18
D12.776.467.374.750.500 Lymphotoxin-alpha 17
D12.776.467.374.750.505 Lymphotoxin alpha1, beta2 Heterotrimer
D12.776.467.374.750.515 Lymphotoxin-beta
D12.776.467.374.750.531 OX40 Ligand 1
D12.776.467.374.750.562 RANK Ligand 142
D12.776.467.374.750.625 TNF-Related Apoptosis-Inducing Ligand 38
D12.776.467.374.750.626 Tumor Necrosis Factor-alpha 1 307
D12.776.467.374.750.656 Tumor Necrosis Factor Ligand Superfamily Member 13 2
D12.776.467.374.750.690 Tumor Necrosis Factor Ligand Superfamily Member 14
D12.776.467.374.750.710 Tumor Necrosis Factor Ligand Superfamily Member 15
D23 Biological Factors 143
D23.529 Intercellular Signaling Peptides and Proteins 156
D23.529.374 Cytokines 2 154
D23.529.374.500 Monokines 6
D23.529.374.500.400 Interleukin-1 119
D23.529.374.500.800 Tumor Necrosis Factor-alpha 1 307
D23.529.374.750 Tumor Necrosis Factors 371
D23.529.374.750.030 CD27 Ligand
D23.529.374.750.061 B-Cell Activating Factor 37
D23.529.374.750.065 4-1BB Ligand 1
D23.529.374.750.092 CD30 Ligand 2
D23.529.374.750.124 CD40 Ligand 23
D23.529.374.750.155 Cytokine TWEAK 2
D23.529.374.750.186 Ectodysplasins 4
D23.529.374.750.249 Fas Ligand Protein 18
D23.529.374.750.500 Lymphotoxin-alpha 17
D23.529.374.750.505 Lymphotoxin alpha1, beta2 Heterotrimer
D23.529.374.750.515 Lymphotoxin-beta
D23.529.374.750.531 OX40 Ligand 1
D23.529.374.750.562 RANK Ligand 142
D23.529.374.750.625 TNF-Related Apoptosis-Inducing Ligand 38
D23.529.374.750.626 Tumor Necrosis Factor-alpha 1 307
D23.529.374.750.656 Tumor Necrosis Factor Ligand Superfamily Member 13 2
D23.529.374.750.690 Tumor Necrosis Factor Ligand Superfamily Member 14
D23.529.374.750.710 Tumor Necrosis Factor Ligand Superfamily Member 15

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