Apoptosis Inducing Factor [faktor vyvolávající apoptózu]

topical
10
Terms

AIF
apoptózu indukující faktor

 

AIF Apoptosis Regulatory Protein
Apoptosis-Inducing Factor
Mitochondrial Apoptosis-Inducing Factor

Persistent link   https://www.medvik.cz/link/D051033
Definition

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.

Annotation
INHIBITOR OF APOPTOSIS PROTEINS is also available
DUI
D051033 MeSH Browser
CUI
M0301106
History note
2006(1999)
Public note
2006; APOPTOSIS INDUCING FACTOR was indexed under FLAVOPROTEINS & MEMBRANE PROTEINS 1999-2005

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AG
agonists 0
AN
analysis 1
AI
antagonists & inhibitors 1
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 1
EC
economics 0
GE
genetics 1
HI
history 0
IM
immunology 0
IP
isolation & purification 1
ME
metabolism 3
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 1
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.682 Oxidoreductases 446
D08.811.682.608 NADH, NADPH Oxidoreductases 54
D08.811.682.608.047 Apoptosis Inducing Factor 10
D08.811.682.608.191 Cytochrome Reductases 6
D08.811.682.608.504 Electron Transport Complex I 44
D08.811.682.608.530 NADH Tetrazolium Reductase 1
D08.811.682.608.540 NADP Transhydrogenases 2
D08.811.682.608.550 NADPH Dehydrogenase 14
D08.811.682.608.575 NADPH Oxidases 44
D08.811.682.608.800 Quinone Reductases 7
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 380
D12.644.360 Intracellular Signaling Peptides and Proteins 174
D12.644.360.075 Apoptosis Regulatory Proteins 78
D12.644.360.075.311 Apoptosis Inducing Factor 10
D12.644.360.075.323 Bcl-2-Like Protein 11 5
D12.644.360.075.335 Beclin-1 3
D12.644.360.075.358 CARD Signaling Adaptor Proteins 7
D12.644.360.075.413 DCC Receptor
D12.644.360.075.421 Death Domain Receptor Signaling Adaptor Proteins 5
D12.644.360.075.437 Inhibitor of Apoptosis Proteins 29
D12.644.360.075.718 Proto-Oncogene Proteins c-bcl-2 147
D12.776 Proteins 2 575
D12.776.157 Carrier Proteins 546
D12.776.157.687 Poly-ADP-Ribose Binding Proteins 5
D12.776.157.687.063 Apoptosis Inducing Factor 10
D12.776.157.687.125 Ataxia Telangiectasia Mutated Proteins 89
D12.776.157.687.157 CCCTC-Binding Factor 2
D12.776.157.687.173 Centromere Protein A 2
D12.776.157.687.188 Centromere Protein B
D12.776.157.687.250 Cyclin-Dependent Kinase Inhibitor p21 74
D12.776.157.687.313 DNA (Cytosine-5-)-Methyltransferase 1 7
D12.776.157.687.375 DNA Topoisomerases, Type I 24
D12.776.157.687.438 DNA-Activated Protein Kinase 14
D12.776.157.687.450 Heat Shock Transcription Factors 1
D12.776.157.687.462 Heterogeneous Nuclear Ribonucleoprotein A1
D12.776.157.687.485 Histones 368
D12.776.157.687.493 Ku Autoantigen 5
D12.776.157.687.495 MRE11 Homologue Protein 6
D12.776.157.687.496 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.157.687.497 NF-kappa B p52 Subunit 2
D12.776.157.687.499 Nicotinamide-Nucleotide Adenylyltransferase 3
D12.776.157.687.575 Nitric Oxide Synthase Type II 75
D12.776.157.687.613 Telomerase 189
D12.776.157.687.650 Tumor Suppressor Protein p53 755
D12.776.157.687.750 Werner Syndrome Helicase 2
D12.776.157.687.813 X-ray Repair Cross Complementing Protein 1 9
D12.776.157.687.875 Xeroderma Pigmentosum Group A Protein 2
D12.776.331 Flavoproteins 24
D12.776.331.049 Acetolactate Synthase 5
D12.776.331.099 Acyl-CoA Dehydrogenase 10
D12.776.331.102 Acyl-CoA Dehydrogenase, Long-Chain 4
D12.776.331.149 Acyl-CoA Oxidase 1
D12.776.331.161 Apoptosis Inducing Factor 10
D12.776.331.174 Butyryl-CoA Dehydrogenase
D12.776.331.180 Cryptochromes 12
D12.776.331.186 Cytochrome-B(5) Reductase 5
D12.776.331.192 Dihydrolipoamide Dehydrogenase 17
D12.776.331.199 Electron-Transferring Flavoproteins 1
D12.776.331.400 Flavodoxin 1
D12.776.331.737 Glutamate Synthase (NADH)
D12.776.331.775 Methylenetetrahydrofolate Reductase (NADPH2) 69
D12.776.331.887 NADH Dehydrogenase 14
D12.776.331.894 NADPH Oxidases 44
D12.776.331.899 Nitrate Reductase (NADH) 1
D12.776.331.901 Nitrate Reductase (NAD(P)H)
D12.776.331.911 Nitrate Reductase (NADPH) 1
D12.776.331.915 Retinal Dehydrogenase 2
D12.776.331.943 Sarcosine Oxidase 1
D12.776.331.971 Thioredoxin-Disulfide Reductase 13
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.075 Apoptosis Regulatory Proteins 78
D12.776.476.075.311 Apoptosis Inducing Factor 10
D12.776.476.075.323 Bcl-2-Like Protein 11 5
D12.776.476.075.335 Beclin-1 3
D12.776.476.075.358 CARD Signaling Adaptor Proteins 7
D12.776.476.075.405 Caspases 157
D12.776.476.075.413 DCC Receptor
D12.776.476.075.421 Death Domain Receptor Signaling Adaptor Proteins 5
D12.776.476.075.429 High-Temperature Requirement A Serine Peptidase 2
D12.776.476.075.437 Inhibitor of Apoptosis Proteins 29
D12.776.476.075.718 Proto-Oncogene Proteins c-bcl-2 147
D12.776.660 Nuclear Proteins 452
D12.776.660.720 Poly-ADP-Ribose Binding Proteins 5
D12.776.660.720.063 Apoptosis Inducing Factor 10
D12.776.660.720.125 Ataxia Telangiectasia Mutated Proteins 89
D12.776.660.720.157 CCCTC-Binding Factor 2
D12.776.660.720.173 Centromere Protein A 2
D12.776.660.720.188 Centromere Protein B
D12.776.660.720.250 Cyclin-Dependent Kinase Inhibitor p21 74
D12.776.660.720.313 DNA (Cytosine-5-)-Methyltransferase 1 7
D12.776.660.720.375 DNA Topoisomerases, Type I 24
D12.776.660.720.438 DNA-Activated Protein Kinase 14
D12.776.660.720.462 Heat Shock Transcription Factors 1
D12.776.660.720.485 Histones 368
D12.776.660.720.493 Ku Autoantigen 5
D12.776.660.720.495 MRE11 Homologue Protein 6
D12.776.660.720.496 Myristoylated Alanine-Rich C Kinase Substrate
D12.776.660.720.497 NF-kappa B p52 Subunit 2
D12.776.660.720.499 Nicotinamide-Nucleotide Adenylyltransferase 3
D12.776.660.720.575 Nitric Oxide Synthase Type II 75
D12.776.660.720.613 Telomerase 189
D12.776.660.720.650 Tumor Suppressor Protein p53 755
D12.776.660.720.750 Werner Syndrome Helicase 2
D12.776.660.720.813 X-ray Repair Cross Complementing Protein 1 9
D12.776.660.720.875 Xeroderma Pigmentosum Group A Protein 2

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