Anaphase-Promoting Complex-Cyclosome [anafázi podporující komplex]

topical
12
Terms

cyklosom
cyklosom APC/C
cyklozom
cyklozom APC/C
komplex APC
komplex podporující anafázi
proteinový komplex APC

 

Anaphase Promoting Complex

Persistent link   https://www.medvik.cz/link/D064173
Definition

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

DUI
D064173 MeSH Browser
CUI
M0580077
Previous indexing
Ligases (1992-2003); Ubiquitin-Protein Ligase Complexes (2004-2013)
History note
2014
Public note
2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013

Allowable subheadings

AD
administration & dosage 0
AE
adverse effects 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CF
cerebrospinal fluid 0
CS
chemical synthesis 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
EC
economics 0
GE
genetics 0
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 6
PK
pharmacokinetics 0
PD
pharmacology 0
PH
physiology 0
PO
poisoning 0
RE
radiation effects 0
ST
standards 0
SD
supply & distribution 0
TU
therapeutic use 0
TO
toxicity 0
UL
ultrastructure 0
UR
urine 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.464 Ligases 33
D08.811.464.938 Ubiquitin-Protein Ligase Complexes 25
D08.811.464.938.750 Ubiquitin-Protein Ligases 80
D08.811.464.938.750.092 Anaphase-Promoting Complex-Cyclosome 12
D08.811.464.938.750.092.500 Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.625 Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.687 Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.750 Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.875 Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.937 Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.968 Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.984 Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.992 Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.996 Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
D08.811.464.938.750.092.998 Cdc20 Proteins 1
D08.811.464.938.750.092.999 Cdh1 Proteins 1
D08.811.464.938.750.186 Fanconi Anemia Complementation Group L Protein 2
D08.811.464.938.750.210 Inhibitor of Apoptosis Proteins 29
D08.811.464.938.750.233 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein 1
D08.811.464.938.750.257 Nedd4 Ubiquitin Protein Ligases
D08.811.464.938.750.280 Polycomb Repressive Complex 1 6
D08.811.464.938.750.374 Proto-Oncogene Proteins c-cbl 5
D08.811.464.938.750.562 Proto-Oncogene Proteins c-mdm2 65
D08.811.464.938.750.656 Receptors, Autocrine Motility Factor 1
D08.811.464.938.750.703 Seven in Absentia Proteins
D08.811.464.938.750.750 SKP Cullin F-Box Protein Ligases 14
D08.811.464.938.750.782 Tripartite Motif-Containing Protein 28
D08.811.464.938.750.813 Tumor Necrosis Factor alpha-Induced Protein 3 1
D08.811.464.938.750.875 Von Hippel-Lindau Tumor Suppressor Protein 30
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.167 Cell Cycle Proteins 328
D12.776.167.024 Anaphase-Promoting Complex-Cyclosome 12
D12.776.167.024.500 Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.625 Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.687 Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.750 Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.875 Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.937 Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.968 Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.984 Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.992 Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.996 Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
D12.776.167.024.998 Cdc20 Proteins 1
D12.776.167.024.999 Cdh1 Proteins 1
D12.776.167.049 Aurora Kinases 4
D12.776.167.100 cdc25 Phosphatases 28
D12.776.167.150 Cellular Apoptosis Susceptibility Protein 4
D12.776.167.163 Cohesins
D12.776.167.175 Cullin Proteins 7
D12.776.167.187 Cyclin-Dependent Kinase Inhibitor Proteins 42
D12.776.167.200 Cyclin-Dependent Kinases 228
D12.776.167.218 Cyclins 112
D12.776.167.242 F-Box-WD Repeat-Containing Protein 7 3
D12.776.167.254 GADD45 Proteins
D12.776.167.265 Geminin 1
D12.776.167.313 Mad2 Proteins 1
D12.776.167.409 Minichromosome Maintenance Proteins 4
D12.776.167.457 NIMA-Related Kinases 4
D12.776.167.469 Polo-like Kinases
D12.776.167.481 S100 Calcium Binding Protein A6 2
D12.776.167.504 Securin 1
D12.776.167.552 Separase 1
D12.776.167.564 Structural Maintenance of Chromosome Protein 1
D12.776.167.576 Survivin 6
D12.776.167.600 Tumor Suppressor Protein p14ARF 4
D12.776.167.800 Valosin Containing Protein 2

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