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Anaphase-Promoting Complex-Cyclosome [anafázi podporující komplex]

topical

12

Terms: cyklosom
cyklosom APC/C
cyklozom
cyklozom APC/C
komplex APC
komplex podporující anafázi
proteinový komplex APC

: Anaphase Promoting Complex

Persistent link https://www.medvik.cz/link/D064173

Definition

An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.

DUI: D064173 MeSH Browser
CUI: M0580077
Previous indexing: Ubiquitin-Protein Ligase Complexes (2004-2013); Ligases (1992-2003)
History note: 2014
Public note: 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013

Allowable subheadings

AD: administration & dosage
AE: adverse effects
AN: analysis
AI: antagonists & inhibitors
BI: biosynthesis
BL: blood
CF: cerebrospinal fluid
CS: chemical synthesis
CH: chemistry
CL: classification
DF: deficiency
DE: drug effects
EC: economics
GE: genetics
HI: history
IM: immunology
IP: isolation & purification
ME: metabolism 6
PK: pharmacokinetics
PD: pharmacology
PH: physiology
PO: poisoning
RE: radiation effects
ST: standards
SD: supply & distribution
TU: therapeutic use
TO: toxicity
UL: ultrastructure
UR: urine

... Occurrences in Medvik records

D Chemicals and Drugs

D08 Enzymes and Coenzymes 7

D08.811 Enzymes 1 551

D08.811.464 Ligases 33

D08.811.464.938 Ubiquitin-Protein Ligase Complexes 25

D08.811.464.938.750 Ubiquitin-Protein Ligases 81

D08.811.464.938.750.092 Anaphase-Promoting Complex-Cyclosome 12

D08.811.464.938.750.092.500 Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.625 Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.687 Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.750 Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.875 Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.937 Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.968 Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.984 Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.992 Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.996 Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome

D08.811.464.938.750.092.998 Cdc20 Proteins 1

D08.811.464.938.750.092.999 Cdh1 Proteins 1

D08.811.464.938.750.186 Fanconi Anemia Complementation Group L Protein 2

D08.811.464.938.750.210 Inhibitor of Apoptosis Proteins 29

D08.811.464.938.750.233 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein 1

D08.811.464.938.750.257 Nedd4 Ubiquitin Protein Ligases

D08.811.464.938.750.280 Polycomb Repressive Complex 1 6

D08.811.464.938.750.374 Proto-Oncogene Proteins c-cbl 6

D08.811.464.938.750.562 Proto-Oncogene Proteins c-mdm2 65

D08.811.464.938.750.656 Receptors, Autocrine Motility Factor 1

D08.811.464.938.750.703 Seven in Absentia Proteins

D08.811.464.938.750.750 SKP Cullin F-Box Protein Ligases 14

D08.811.464.938.750.782 Tripartite Motif-Containing Protein 28

D08.811.464.938.750.813 Tumor Necrosis Factor alpha-Induced Protein 3 2

D08.811.464.938.750.875 Von Hippel-Lindau Tumor Suppressor Protein 31

D12 Amino Acids, Peptides, and Proteins 16

D12.776 Proteins 2 581

D12.776.167 Cell Cycle Proteins 330

D12.776.167.024 Anaphase-Promoting Complex-Cyclosome 12

D12.776.167.024.500 Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.625 Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.687 Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.750 Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.875 Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.937 Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.968 Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.984 Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.992 Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.996 Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome

D12.776.167.024.998 Cdc20 Proteins 1

D12.776.167.024.999 Cdh1 Proteins 1

D12.776.167.049 Aurora Kinases 4

D12.776.167.100 cdc25 Phosphatases 28

D12.776.167.150 Cellular Apoptosis Susceptibility Protein 4

D12.776.167.163 Cohesins

D12.776.167.175 Cullin Proteins 7

D12.776.167.187 Cyclin-Dependent Kinase Inhibitor Proteins 44

D12.776.167.200 Cyclin-Dependent Kinases 231

D12.776.167.218 Cyclins 112

D12.776.167.242 F-Box-WD Repeat-Containing Protein 7 3

D12.776.167.254 GADD45 Proteins

D12.776.167.265 Geminin 1

D12.776.167.313 Mad2 Proteins 1

D12.776.167.409 Minichromosome Maintenance Proteins 4

D12.776.167.457 NIMA-Related Kinases 4

D12.776.167.469 Polo-like Kinases

D12.776.167.481 S100 Calcium Binding Protein A6 2

D12.776.167.504 Securin 1

D12.776.167.552 Separase 1

D12.776.167.564 Structural Maintenance of Chromosome Protein 1

D12.776.167.576 Survivin 6

D12.776.167.600 Tumor Suppressor Protein p14ARF 4

D12.776.167.800 Valosin Containing Protein 3

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