We have studied serum erythropoietin (EPO) levels, serum creatinine and blood hemoglobin and hematocrit levels in the group of 140 patients after kidney transplantation. All patients received conventional immunosuppressive therapy consisting of cyclosporine (Sandimmune Neoral), azathioprin (Imuran) and steroids (Prednison). The aim of the study was to investigate the relationship between serum EPO, serum creatinine and hematologic parameters. Complete restoration of hemoglobin and hematocrit levels was obtained in 99 patients (70.7%), moderate degree of anaemia with average hemoglobin level 114.7 +/- 12.3 g/l was seen in 37 patients (26.4%) and four patients (2.9%) had posttransplant erythrocytosis. Normal hemoglobin values are generally restored during 3 months after successful renal transplantation. Statistical analysis confirmed significant correlation (p < 0.001) between graft function and hematologic parameters, but none correlation was found neither between serum EPO levels and serum creatinine and not between serum EPO levels and hemoglobin/hematocrit values. Plasma creatinine is not reliable indicator of renal EPO secretory capacity. The degree of correction of anemia is limited by the stage of graft function and correlates with the serum creatinine concentration. The results suggest, that the restoration of normal excretory graft function after transplantation improves bone marrow response to EPO and leads to normalization of erythropoietic activity.

• MeSH
• dospělí MeSH
• erythropoetin krev   MeSH
• hematokrit * MeSH
• imunosupresiva terapeutické užití   MeSH
• kreatinin krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• monitorování fyziologických funkcí MeSH
• senioři MeSH
• transplantace ledvin imunologie   fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

Stenosis or thrombosis of the central venous tract (axillaris or subclavian vein) may be after creation of arteriovenous fistula for hemodialysis the cause of manifestation of venous hypertension. The authors evaluate positive bypass to internal jugular vein in the therapy of this complication.

• MeSH
• arteriovenózní zkrat škodlivé účinky   MeSH
• dialýza ledvin * MeSH
• dospělí MeSH
• hypertenze etiologie   terapie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• retrospektivní studie MeSH
• vena axillaris chirurgie   MeSH
• vena subclavia chirurgie   MeSH
• venae jugulares chirurgie   MeSH
• žilní trombóza etiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH