The aim of this study was to investigate differences in the relative distributions of subsets of natural killer (NK) cells, including immunoregulatory NK cells (CD56(+)CD16(-)), cytotoxic NK cells (CD56(+)CD16(+)), as well as total NK cells (CD56(+)CD3(-)), and NKT cells (CD56(+)CD3(+)) in peripheral blood and follicular fluid in subjects with successful or unsuccessful IVF treatment. The immunoregulatory NK cell population in follicular fluid of women who failed to achieve pregnancy after IVF treatment was significantly decreased compared to women who became pregnant after IVF. Conversely, the NKT cell population in the follicular fluid of women with unsuccessful treatment was significantly elevated compared with those with successful IVF. Understanding the changes in the distribution of NK and NKT cell populations in follicular fluid might serve as the basis for a more detailed study to determine whether NK cell parameters have prognostic value in guiding the selection of individual ova for use in IVF procedures.
- MeSH
- biologické markery metabolismus MeSH
- buňky NK imunologie metabolismus patologie MeSH
- CD antigeny biosyntéza MeSH
- dospělí MeSH
- fertilizace in vitro MeSH
- folikulární tekutina cytologie imunologie metabolismus MeSH
- lidé MeSH
- NKT buňky imunologie metabolismus patologie MeSH
- počet buněk MeSH
- prognóza MeSH
- průtoková cytometrie MeSH
- separace buněk MeSH
- těhotenství MeSH
- výsledek terapie MeSH
- ženská infertilita krev diagnóza patologie patofyziologie terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
