The adverse impact of cytomegalovirus (CMV) infection after solid organ transplantion is currently believed to be mediated primarily by its immunomodulatory effects. There is a large body of evidence showing that both CMV disease and asymptomatic viremia are independent risk factors for the development of allograft rejection. The aim of this article is to summarize mechanisms whereby CMV is involved in the development and progression of allograft rejection, with particular emphasis on renal transplant recipients. The article will also address the potential of anti-CMV preventive protocols designed to favorably affect the incidence of allograft rejection.

• MeSH
• antivirové látky terapeutické užití   MeSH
• chemoprofylaxe MeSH
• cytomegalovirové infekce imunologie   prevence a kontrola   virologie   MeSH
• Cytomegalovirus účinky léků   MeSH
• homologní transplantace škodlivé účinky   MeSH
• lidé MeSH
• rejekce štěpu epidemiologie   imunologie   prevence a kontrola   virologie   MeSH
• transplantace ledvin škodlivé účinky   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH