Alterations in geometry and structure of coronary arteries have marked consequences on blood flow to the respective area. We evaluated long-term effect of losartan on blood pressure (BP), heart weight/body weight (HW/BW), geometry and structure of septal branch of coronary artery (RS) of young SHR and Wistar rats. Four-week-old Wistar rats and SHR were used. Losartan was administered (20 mg/kg/day) in drinking water by gavage for 5 weeks. BP was measured by plethysmographic method. Cardiovascular system was perfused with a fixative (120 mm Hg). RS was processed for electron microscopy. Wall thickness of intima + media (WT), inner diameter (ID), cross-sectional area of intima + media (CSA), volume densities (VD) of endothelial cells (EC), extracellular matrix (ECM) of intima, smooth muscle cells (SMC) and ECM of media were evaluated. BP of 4-week-old SHR did not differ from that of Wistar rats. BP, HW/BW, WT, CSA, WT/ID, CSAs of SMC, ECM of media were increased in 9-week-old SHR, whereas their VD and CSA of EC were decreased. Losartan administration decreased BP and HW/BW in both groups. Geometry of RS was affected only in SHR (reduction of WT, CSA, WT/ID and increased of ID, circumferential tension, VD and CSA of EC). Losartan administration reduced BP and myocardial mass in both groups and beneficially affected geometry and structure of coronary artery in SHR.

• MeSH
• antihypertenziva aplikace a dávkování   MeSH
• blokátory receptoru 1 pro angiotenzin II aplikace a dávkování   MeSH
• financování organizované MeSH
• hypertenze MeSH
• kardiomegalie MeSH
• koronární cévy účinky léků   ultrastruktura   MeSH
• krevní tlak účinky léků   MeSH
• krysa rodu rattus MeSH
• losartan antagonisté a inhibitory   aplikace a dávkování   MeSH
• modely nemocí na zvířatech MeSH
• myokard patologie   MeSH
• potkani inbrední SHR MeSH
• potkani Wistar MeSH
• rozvrh dávkování léků MeSH
• srdce účinky léků   MeSH
• tunica intima účinky léků   ultrastruktura   MeSH
• tunica media účinky léků   ultrastruktura   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• zvířata MeSH