Six patients with alternating hemiplegia in childhood (AHC) were followed, some of them up to childhood. Progressive intellectual deterioration and disturbance of pyramidal, extrapyramidal and cerebellar functions were found in all of them. Multimodal evoked potential abnormalities, changes of sleep structure and HMPAO-SPECT results were correlated with increasing clinical handicap. In older patients increases in the plasma level of lactate, as well as in the lactate: pyruvate ratio, were revealed, accompanied by elevated inorganic phosphate (Pi) values on 31P MR spectroscopy. These findings support the hypothesis of a possible secondary mitochondrial deficit in AHC. However, no specific bioptic changes (muscle, skin, or buccal mucous membrane) were found, and thus the etiology of AHC remains unclear.

• MeSH
• dítě MeSH
• dospělí MeSH
• elektroencefalografie MeSH
• elektromyografie MeSH
• energetický metabolismus fyziologie   MeSH
• flunarizin terapeutické užití   MeSH
• hemiplegie farmakoterapie   patologie   radiografie   MeSH
• jednofotonová emisní výpočetní tomografie MeSH
• kyselina mléčná MeSH
• kyselina pyrohroznová MeSH
• laktáty krev   MeSH
• lidé MeSH
• mladiství MeSH
• průřezové studie MeSH
• pyruváty krev   MeSH
• sluchové evokované potenciály fyziologie   MeSH
• spánek fyziologie   MeSH
• svalová spasticita patologie   MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH
• klinické zkoušky MeSH