This review describes a drug target for cancer therapy, family of phosphatidylinositol-3 kinase related kinases (PIKKs), and it gives a comprehensive review of recent information. Besides general information about phosphatidylinositol-3 kinase superfamily, it characterizes a DNA-damage response pathway since it is monitored by PIKKs.

• MeSH
• Cell Cycle MeSH
• DNA-Binding Proteins MeSH
• Class I Phosphatidylinositol 3-Kinases MeSH
• Class II Phosphatidylinositol 3-Kinases MeSH
• Class III Phosphatidylinositol 3-Kinases MeSH
• Phosphatidylinositol 3-Kinases * physiology   genetics   MeSH
• Phosphatidylinositol-4-Phosphate 3-Kinase MeSH
• Radiation, Ionizing * MeSH
• Humans MeSH
• Tumor Suppressor Proteins physiology   genetics   MeSH
• Tumor Suppressor Protein p53 physiology   genetics   MeSH
• Neoplasms genetics   radiotherapy   MeSH
• DNA Repair genetics   MeSH
• DNA Damage * radiation effects   MeSH
• Protein Serine-Threonine Kinases physiology   genetics   MeSH
• Cell Cycle Proteins physiology   genetics   MeSH
• Radiotherapy adverse effects   MeSH
• Ataxia Telangiectasia genetics   MeSH
• TOR Serine-Threonine Kinases physiology   genetics   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH