High incidence of infertility along with low vitamin D levels was detected in otherwise healthy young men. The aim is to observe the effect of vitamin D supplementation on semen parameters as assessed by semen analysis in infertile men. In total, 45 men (mean age 36.6 years) in consecutive order were included, of whom 34 finished the study. Subjects were supplemented by vitamin D (cholecalciferol) 2500 IU/day. Vitamin D levels were assessed by HPLC. Semen analysis was performed strictly following 2010 WHO guidelines. Study periods were baseline and month 6. During follow-up, 20 %, 7.4 %, 22 % and 0.7 % increase in serum vitamin D levels, progressive sperm motility, sperm concentration and sperm morphology, respectively, were observed (all p<0.05). At follow-up end, 9 patients (26 %) reached normal sperm parameters of whom 2 fertilized their partner. There was no correlation between vitamin D and semen parameters observed. This study proves that vitamin D supplementation is possibly a modulator of sperm parameters in vitamin D deficient, otherwise healthy men. Although a direct relationship between vitamin D and sperm parameters was not observed obtaining adequate vitamin D levels could likely play a role in the male factor of infertility.
- MeSH
- Cholecalciferol pharmacology therapeutic use MeSH
- Adult MeSH
- Humans MeSH
- Infertility, Male diet therapy MeSH
- Dietary Supplements MeSH
- Prospective Studies MeSH
- Semen drug effects MeSH
- Spermatozoa drug effects MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
The pelvic pain treatment is a quite complicated problem with little success in determing its patophysical causes. The permanent or repeated chronic non-malignant pain, accompanied by functional involvement amplified by mental factors, will often end in a sexual dysfunction. Material and methods: Our team of authors from the Department of Urology of the University Hospital Ruzinov in Bratislava is presenting a group of patiens from 2005-2007, who suffered from severe pelvic pain for at least 6 months. The patiens, all with various diagnosises, were treated by using an intracavitary instillation of hyaluronic acid directly into the bladder. Results: After completing this treatment, we evaluated the various changes in CPP (chronic pelvic pain) before and after treatment by means of questionnaires. After the treatment, the patients reported a 64% overall improvement: 45% improvement in bladder control, 31% improvement in pain during or after sexual intercourse, 37% improvement in sexual function satisfaction, and 66% improvement in overall quality of life. Conclusions: Our goal is to present the intracavitary instillation of hyaluronic acid as a safe, well-tolerated, treatment with easy application. Its application can be done in a clinical environment; another significant fact when considering the pharmacoeconomic factor of PBS/IC treatment.
