- MeSH
- Diabetes, Gestational MeSH
- Immunosuppressive Agents therapeutic use MeSH
- Immunosuppression Therapy methods MeSH
- Drug Therapy, Combination methods MeSH
- Pregnancy Complications MeSH
- Skin Care MeSH
- Pyoderma Gangrenosum * complications therapy MeSH
- Pregnancy MeSH
- Colitis, Ulcerative MeSH
- Check Tag
- Pregnancy MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Adult MeSH
- Immunosuppressive Agents therapeutic use MeSH
- Immunosuppression Therapy methods MeSH
- Drug Therapy, Combination methods MeSH
- Pregnancy Complications MeSH
- Humans MeSH
- Skin Care methods MeSH
- Pyoderma Gangrenosum * complications therapy MeSH
- Pregnancy MeSH
- Colitis, Ulcerative MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Autoři popisují případ gravidní 34leté nemocné s potvrzenou diagnózou pyoderma gangrenosum. Systémová kortikoidní terapie nevedla k ústupu obtíží, proto byla zahájena kombinovaná imunosupresivní léčba (kortikoidy, cyklosporin A a mykofenolát-mofetil), která vedla k postupnému hojení projevů. Komplikací byl vznik gestačního a steroidního diabetu. Po roce a půl od počátku kožních potíží došlo k manifestaci ulcerózní kolitidy. Léčba infliximabem vedla k remisi pyoderma gangrenosum a ulcerózní kolitidy a k ukončení ostatní imunosupresivní léčby. Článek poskytuje přehled současných poznatků o diagnostice a možnostech terapie tohoto onemocnění.
The authors present a case of a 34-year-old pregnant patient with confirmed diagnosis of pyoderma gangrenosum (PG). As systemic corticosteroid therapy had not resulted in lesion clearing, combined immunosupressive treatment (corticosteroids, cyclosporine A and mycophenolate mofetil) was administered that led to gradual healing of the lesions. Steroid and gestational diabetes developed as complications of therapy. Furthermore, ulcerative colitis was diagnosed year and a half after the appearance of skin lesions. The administration of infliximab led to remission of PG as well as ulcerative colitis and enabled the discontinuation of previous combined immosuppresive treatment. The article reviews recent knowledge of diagnostics and therapeutical approaches in this disease.
- MeSH
- Diagnosis, Differential MeSH
- Adult MeSH
- Diabetes, Gestational MeSH
- Glucocorticoids administration & dosage adverse effects therapeutic use MeSH
- Hepatitis E chemically induced diet therapy MeSH
- Immunosuppressive Agents administration & dosage adverse effects therapeutic use MeSH
- Infliximab administration & dosage therapeutic use MeSH
- Drug Therapy, Combination MeSH
- Pregnancy Complications * MeSH
- Humans MeSH
- Forearm pathology MeSH
- Pyoderma Gangrenosum * diagnosis drug therapy pathology MeSH
- Colitis, Ulcerative diagnosis drug therapy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
