Autoři popisují případ 55leté ženy s 5 let trvající tvorbou hlubokých ulcerací na trupu i končetinách vzniklých na podkladě non-uremické kalcifylaxe dosahujících celkové plochy až 988 cm2. Léčba kortikosteroidy a azathioprinem byla bez efektu. Nasazení apremilastu vedlo ke zhojení 97 % plochy vředů. Apremilast může představovat alternativu léčby tohoto onemocnění.
The authors report a case of a 55-year-old woman, who has been developing deep ulcers on the trunk and limbs for 5 years. They were based on non-uremic calciphylaxis and extended to the total area of 988 cm2. Treatment with corticosteroids and azathioprine was not successful, the administration of apremilast led to healing of 97% of the ulcers. Apremilast could represent a new alternative in the treatment of this disease.
- Keywords
- non-uremická kalcifylaxe, apremilast,
- MeSH
- Anti-Inflammatory Agents, Non-Steroidal therapeutic use MeSH
- Immunosuppression Therapy MeSH
- Phosphodiesterase 4 Inhibitors therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Pyoderma Gangrenosum * physiopathology therapy MeSH
- Thalidomide analogs & derivatives therapeutic use MeSH
- Treatment Outcome MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Comorbidity MeSH
- Hemorrhage etiology MeSH
- Melanoma * diagnosis MeSH
- Foreskin * pathology MeSH
- Aged, 80 and over MeSH
- Check Tag
- Male MeSH
- Aged, 80 and over MeSH
- Publication type
- Case Reports MeSH
